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Type:	Artigo de Periódico
Title:	Phthalazine-triones: calix[4]arene-assisted synthesis using green solvents and their anticancer activities against human cancer cells
Authors:	Yuri de Freitas Rego Cleiton Moreira da Silva Daniel Leite da Silva Jeferson Jeferson Gomes Ana Lucia Tasca Gois Ruiz João Ernesto de Carvalho Sergio Antonio Fernandes Ângelo de Fátima
Abstract:	Fourteen phthalazine-triones bearing different substituents at C-4 position were synthesized through multicomponent reactions (MCR) by using phthalhydrazide, dimedone and diferent aldehydes as starting materials, p-sulfonic acid calix[4]arene as catalyst and ethyl lactate as solvent under microwave irradiation. Compounds 7–16 were obtained in excellent to moderate yields (94–51%) in only 10 min of reaction using this methodology. The antiproliferative activity against cancer cells was disclosed, for the first time, for synthesized compounds. The capacity of all compounds to inhibit cancer cells growth was dependent on the histological origin of cells. Compound 20 was active against more than one strain.
Subject:	Compostos heterocíclicos Catalise Microondas Calixarenos Agentes antineoplasicos
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	ICX - DEPARTAMENTO DE QUÍMICA
Rights:	Acesso Aberto
metadata.dc.identifier.doi:	https://doi.org/10.1016/j.arabjc.2016.04.007
URI:	http://hdl.handle.net/1843/77226
Issue Date:	2019
metadata.dc.url.externa:	https://www.sciencedirect.com/science/article/pii/S1878535216300314
metadata.dc.relation.ispartof:	Arabian Journal of Chemistry
Appears in Collections:	Artigo de Periódico

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