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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/78304
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dc.creatorValéria Sutana Ladeirapt_BR
dc.creatorSílvia Letícia de Oliveira Toledopt_BR
dc.creatorLetícia Gonçalves Resende Ferreirapt_BR
dc.creatorMarina Mendes Oliveirapt_BR
dc.creatorAna Paula Ferreira Silvapt_BR
dc.creatorWander Valadares de Oliveira Jrpt_BR
dc.creatorRita Carolina Figueiredo Duartept_BR
dc.creatorCristiane de Oliveira Renópt_BR
dc.creatorLuci Maria Sant'ana Dussept_BR
dc.creatorHérica Lima dos Santospt_BR
dc.creatorMaria das Graças Carvalhopt_BR
dc.creatorMelina de Barros Pinheiropt_BR
dc.creatorDanyelle Romana Alves Riospt_BR
dc.date.accessioned2024-11-26T23:57:30Z-
dc.date.available2024-11-26T23:57:30Z-
dc.date.issued2021-01-
dc.citation.volume197pt_BR
dc.citation.spage165pt_BR
dc.citation.epage171pt_BR
dc.identifier.doi10.1016/j.thromres.2020.10.040pt_BR
dc.identifier.issn0049-3848pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/78304-
dc.description.resumoAbstract Activation of coagulation is an important hallmark of sickle cell disease (SCD) and it is believed that hypercoagulability plays a role to the disease pathophysiology. Studies have sought to identify how hemostatic biomarkers are expressed in SCD, however, the results are inconclusive. In this context, our objective was to evaluate the thrombin generation in vivo and ex vivo in SCD patients and the association between these biomarkers and the use of HU. This cross-sectional study was carried out with patients diagnosed with SCD, users or not of Hydroxyurea (HU), and healthy individuals as controls. D dimer (D-Di) was evaluated by ELISA and (TGT) thrombin generation test by CAT method. D-Di plasma levels were significantly higher in SCD patients when compared to the controls. TGT parameters such as peak, ETP and normalized ETP at low TF concentration and time-to-peak, peak, ETP and normalized ETP values at high TF concentration were lower in SCD patients than in controls. In contrast, the normalized activated protein C sensitivity ratio (nAPCsr) was higher in patients compared to controls, indicating resistance to the action of this natural anticoagulant. Regarding the use of HU, comparing users and non-users of this drug, no difference was observed in D-Di levels and in most TGT parameters. Our data analyzed together allow us to conclude that patients with SCD present a state of hypercoagulability in vivo due to the higher levels of D-Di and resistance to APC assessed ex vivo which is consistent with the coagulation imbalance described in SCD patients.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofThrombosis Research-
dc.rightsAcesso Restritopt_BR
dc.subjectDoença falciformept_BR
dc.subjectGeração de trombinapt_BR
dc.subjectHipercoagulabilidadept_BR
dc.subject.otherDoença falciformept_BR
dc.titleThrombin generation in vivo and ex vivo in sickle cell disease patientspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0049384820305995pt_BR
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