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http://hdl.handle.net/1843/79382| Type: | Artigo de Periódico |
| Title: | Association between MBL2 haplotypes and dengue severity in children from Rio de Janeiro, Brazil |
| Authors: | Alice Maria de Magalhães Ornelas Caroline Xavier-de-Carvalho Lucia Elena Alvarado-Arnez Marcelo Ribeiro-Alves Átila Duque Rossi Amilcar Tanuri Renato Santana de Aguiar Milton Ozório Moraes Cynthia Chester Cardoso |
| Abstract: | BACKGROUND Dengue is an arthropod-borne viral disease with a majority of asymptomatic individuals and clinical manifestations varying from mild fever to severe and potentially lethal forms. An increasing number of genetic studies have outlined the association between host genetic variations and dengue severity. Genes associated to viral recognition and entry, as well as those encoding mediators of the immune response against infection are strong candidates for association studies. OBJECTIVES The aim of this study was to investigate the association between MBL2, CLEC5A, ITGB3 and CCR5 genes and dengue severity in children. METHODS A matched case-control study was conducted and 19 single nucleotide polymorphisms (SNPs) were investigated. FINDINGS No associations were observed in single SNP analysis. However, when MBL2 SNPs were combined in haplotypes, the allele rs7095891G/rs1800450C/ rs1800451C/rs4935047A/rs930509G/rs2120131G/rs2099902C was significantly associated to risk of severe dengue under α = 0.05 (aOR = 4.02; p = 0.02). A second haplotype carrying rs4935047G and rs7095891G alleles was also associated to risk (aOR = 1.91; p = 0.04). MAIN CONCLUSIONS This is the first study to demonstrate the association between MBL2 haplotypes and dengue severity in Brazilians including adjustment for genetic ancestry. These results reinforce the role of mannose binding lectin in immune response to DENV. |
| Subject: | Genética Vírus da dengue Pesquisa imunológica |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS |
| Rights: | Acesso Aberto |
| URI: | http://hdl.handle.net/1843/79382 |
| Issue Date: | 2019 |
| metadata.dc.url.externa: | https://www.arca.fiocruz.br/handle/icict/33446 |
| metadata.dc.relation.ispartof: | Memórias do Instituto Oswaldo Cruz |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Association between MBL2 haplotypes and dengue severity (1).pdf | 315.67 kB | Adobe PDF | View/Open |
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