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http://hdl.handle.net/1843/79415| Type: | Artigo de Periódico |
| Title: | Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil |
| Authors: | Nuno Faria John McCrone Ruben Hulswit Lucas Franco Mariana Ramundo Jaqueline de Jesus Pamela. Andrade Thais Coletti Giulia Ferreira Camila Silva Erika Manuli Thomas Mellan Rafael Pereira Pedro Peixoto Moritz Kraemer Nelson Gaburo Cecilia da Camilo Henrique Hoeltgebaum William Souza Esmenia Rocha Leandro de Souza Mariana de Pinho Charles Whittaker Leonardo Araujo Frederico Malta Aline de Lima Joice do Silva Danielle Zauli Alessandro de Ferreira Ricardo Schnekenberg Daniel Laydon Patrick Walker Hannah Schlüter Ingra Claro Ana dos Santos Maria Vidal Valentina Del Caro Rosinaldo Filho Helem Dos Santos Renato Santana de Aguiar José Proença-Modena Bruce Nelson James Hay Mélodie Monod Darlan da Candido Xenia Miscouridou Helen Coupland Raphael Sonabend Michaela Vollmer Axel Gandy Carlos Prete Vitor Nascimento Marc Suchard Thomas Bowden Sergei Pond Swapnil Mishra Chieh-hsi Wu Oliver Ratmann Neil Ferguson Christopher Dye Nick Loman Philippe Lemey Andrew Rambaut Nelson Fraiji Maria do Carvalho Oliver Pybus Myuki Crispim Seth Flaxman Samir Bhatt Ester Sabino Flavia Sales Iwona Hawryluk |
| Abstract: | Cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Manaus, Brazil,resurged in late 2020 despite previously high levels of infection. Genome sequencing of viruses sampledin Manaus between November 2020 and January 2021 revealed the emergence and circulation of anovel SARS-CoV-2 variant of concern. Lineage P.1 acquired 17 mutations, including a trio in thespike protein (K417T, E484K, and N501Y) associated with increased binding to the human ACE2(angiotensin-converting enzyme 2) receptor. Molecular clock analysis shows that P.1 emergenceoccurred around mid-November 2020 and was preceded by a period of faster molecular evolution. Usinga two-category dynamical model that integrates genomic and mortality data, we estimate that P.1may be 1.7- to 2.4-fold more transmissible and that previous (non-P.1) infection provides 54 to 79% ofthe protection against infection with P.1 that it provides against non-P.1 lineages. Enhanced globalgenomic surveillance of variants of concern, which may exhibit increased transmissibility and/or immuneevasion, is critical to accelerate pandemic responsiveness. |
| Subject: | COVID-19 (Doença) SARS-CoV-2 Pandemia Microbiologia |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https:// doi:10.1126/science.abh2644 |
| URI: | http://hdl.handle.net/1843/79415 |
| Issue Date: | 14-Apr-2021 |
| metadata.dc.url.externa: | https://www.science.org/doi/full/10.1126/science.abh2644?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org |
| metadata.dc.relation.ispartof: | Science |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Genomics and epidemiology of the P.1 SARS-CoV-2lineage in Manaus, Brazil.pdf | 8.78 MB | Adobe PDF | View/Open |
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