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http://hdl.handle.net/1843/79419| Type: | Artigo de Periódico |
| Title: | Antitumor effect of selenium-rich Brazil nuts and selenomethionine dietary supplementation on pre-existing 4T1 mammary tumor growth in mice |
| Authors: | Marina Apocalypse Nogueira Pereira Ediu Carlos da Silva Junior Istefani Luciene Dayse da Silva Bárbara Andrade de Carvalho Enio Ferreira Eric Francelino Andrade Luiz Roberto Guimarães Guilherme Luciano José Pereira |
| Abstract: | Selenium (Se) is an essential micronutrient known to play an important role in the antioxidant system that can potentially influence tumor growth. We aimed to investigate the effects of dietary Se supplementation after detection of 4T1 mammary tumor growth in BALB/c mice. Thirty female mice received subcutaneous inoculation of 4T1 cells. After five days, all animals presenting palpable tumors were randomly assigned to three groups: a control group (Se-control) receiving a diet with adequate Se (0.15 mg/kg) and two other groups that received Se-supplemented diets (1.4 mg/kg of total Se) with either Brazilian nuts (Se-Nuts) or selenomethionine (SeMet). Data were assessed by either One or Two-way ANOVA followed by Tukey’s HSD or Bonferroni’s post hoc tests, respectively. Both Se-supplemented diets reduced tumor volume from the thirteenth day of feeding compared with the Se-adequate (control) diet (p < 0.05). The SeMet group presented a higher Se blood concentration (p < 0.05) than the Se-control group, with the Se-Nuts group presenting intermediate values. Selenoprotein P gene expression in the liver was higher in the Se-Nuts group than in the Se-control group (p < 0.05), while the SeMet group presented intermediate expression. Dietary Se supplementation, starting after detection of 4T1 palpable lesions, reduced tumor volume in mice. |
| Subject: | Tumores Carcinogênese Castanha-do-brasil Nutrição e câncer Mamas - Câncer Câncer |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICB - DEPARTAMENTO DE PATOLOGIA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.1371/journal.pone.0278088 |
| URI: | http://hdl.handle.net/1843/79419 |
| Issue Date: | 12-Jan-2023 |
| metadata.dc.url.externa: | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0278088 |
| metadata.dc.relation.ispartof: | PLOS ONE |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Antitumor effect of selenium-rich Brazil nuts and selenomethionine dietary supplementation on pre-existing 4t1 mammary tumor growth in mice.pdf | 2.01 MB | Adobe PDF | View/Open |
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