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Type:	Artigo de Periódico
Title:	Late-relapsing hepatitis after yellow fever
Authors:	Izabela Maurício Rezende Leonardo Soares Pereira Jordana Rodrigues Barbosa Fradico Marcelo Antônio Pascoal Xavier Pedro Augusto Alves Ana Carolina Campi-Azevedo Elaine Speziali Lívia Zignago Moreira dos Santos Natalia Soares Albuquerque Indiara Penido Tayrine Araujo Santos Ana Paula Dinis Ano Bom Andrea Marques Vieira da Silva Camilla Bayma Fernandes Carlos Eduardo Calzavara Erna Geessien Kroon Olindo Assis Martins-Filho Andréa Teixeira-Carvalho Betânia Paiva Drumond
Abstract:	One patient presented hyporexia, asthenia, adynamia, and jaundice two months after acute yellow fever (YF) onset; plus laboratory tests indicating hepatic cytolysis and a rebound of alanine and aspartate transaminases, and total and direct bilirubin levels. Laboratory tests discarded autoimmune hepatitis, inflammatory or metabolic liver disease, and new infections caused by hepatotropic agents. Anti-YFV IgM, IgG and neutralizing antibodies were detected in different times, but no viremia. A liver biopsy was collected three months after YF onset and tested positive for YFV antigens and wild-type YFV-RNA (364 RNA-copies/gram/liver). Transaminases and bilirubin levels remained elevated for five months, and the arresting of symptoms persisted for six months after the acute YF onset. Several serum chemokines, cytokines, and growth factors were measured. A similar immune response profile was observed in the earlier phases of the disease, followed by more pronounced changes in the later stages, when transaminases levels returned to normal. The results indicated viral persistence in the liver and continual liver cell damage three months after YF onset and reinforced the need for extended follow-ups of YF patients. Further studies to investigate the role of possible viral persistence and the immune response causing relapsing hepatitis following YF are also necessary.
Subject:	Vírus da Febre Amarela Hepatite Flavivirus
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	ICB - DEPARTAMENTO DE MICROBIOLOGIA MED - DEPARTAMENTO DE ANATOMIA PATOLÓGICA E MEDICINA LEGAL
Rights:	Acesso Aberto
metadata.dc.identifier.doi:	https://doi.org/10.3390/v12020222
URI:	http://hdl.handle.net/1843/79929
Issue Date:	17-Feb-2020
metadata.dc.url.externa:	https://www.mdpi.com/1999-4915/12/2/222
metadata.dc.relation.ispartof:	Viruses
Appears in Collections:	Artigo de Periódico

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