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Type:	Artigo de Periódico
Title:	Arthritis-induced alveolar bone loss is associated with changes in the composition of oral microbiota
Authors:	Jôice Dias Corrêa Adriana Machado Saraiva Celso Martins Queiroz-Junior Mila Fernandes Moreira Madeira Poliana Mendes Duarte Mauro Martins Teixeira Danielle Glória Souza Tarcília Aparecida da Silva
Abstract:	Rheumatoid arthritis (RA) and periodontitis (PD) are chronic inflammatory disorders that cause bone loss. PD tends to be more prevalent and severe in RA patients. Previous experimental studies demonstrated that RA triggers alveolar bone loss similarly to PD. The aim of this study was to investigate if arthritis-induced alveolar bone loss is associated with modification in the oral microbiota. Checkerboard DNA-DNA hybridization was employed to analyze forty oral bacterial species in 3 groups of C57BL/6 mice: control (n = 12; without any challenge); Y4 (n = 8; received oral inoculation of Aggregatibacter Actinomycetemcomitans strain FDC Y4) and AIA group (n = 12; chronic antigen-induced arthritis). The results showed that AIA and Y4 group exhibited similar patterns of bone loss. The AIA group exhibited higher counts of most bacterial species analyzed with predominance of Gram-negative species similarly to infection-induced PD. Prevotella nigrescens and Treponema denticola were detected only in the Y4 group whereas Campylobacter showae, Streptococcus mitis and Streptococcus oralis were only found in the AIA group. Counts of Parvimonas micra, Selenomonas Noxia and Veillonella parvula were greater in the AIA group whereas Actinomyces viscosus and Neisseira mucosa were in large proportion in Y4 group. In conclusion, AIA is associated with changes in the composition of the oral microbiota, which might account for the alveolar bone loss observed in AIA mice.
Subject:	Arthritis Microbiota Periodontal diseases Alveolar bone loss Bacteria
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	FAO - DEPARTAMENTO DE CLÍNICA ICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA ICB - DEPARTAMENTO DE FARMACOLOGIA ICB - DEPARTAMENTO DE MICROBIOLOGIA ICB - DEPARTAMENTO DE MORFOLOGIA
Rights:	Acesso Restrito
metadata.dc.identifier.doi:	https://doi.org/10.1016/j.anaerobe.2016.03.006
URI:	http://hdl.handle.net/1843/81666
Issue Date:	Jun-2016
metadata.dc.url.externa:	https://www.sciencedirect.com/science/article/abs/pii/S1075996416300208?via%3Dihub
metadata.dc.relation.ispartof:	Anaerobe
Appears in Collections:	Artigo de Periódico

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