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http://hdl.handle.net/1843/82039| Type: | Artigo de Periódico |
| Title: | Cigarette smoke induces miR-132 in Th17 cells that enhance osteoclastogenesis in inflammatory arthritis |
| Authors: | Paula Barbim Donate Rene D. Oliveira Geraldo Aleixo Passos José Carlos Alves-Filho Thiago Mattar. Cunha Paulo Louzada-Junior Foo Yew Liew Fernando de Queiroz Cunha Kalil Alves de Lima Raphael Sanches Peres Fausto Almeida Sandra Yasuyo Fukada Alves Tarcília Aparecida da Silva Daniele Carvalho Bernardo Nascimento Nerry Tatiana Cecilio Jhimmy Talbot |
| Abstract: | Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by joint destruction and severe morbidity. Cigarette smoking (CS) can exacerbate the incidence and severity of RA. Although Th17 cells and the Aryl hydrocarbon receptor (AhR) have been implicated, the mechanism by which CS induces RA development remains unclear. Here, using transcriptomic analysis, we show that microRNA-132 is specifically induced in Th17 cells in the presence of either AhR agonist or CS-enriched medium. miRNA-132 thus induced is packaged into extracellular vesicles produced by Th17 and acts as a proinflammatory mediator increasing osteoclastogenesis through the down-regulation of COX2. In vivo, articular knockdown of miR-132 in murine arthritis models reduces the number of osteoclasts in the joints. Clinically, RA patients express higher levels of miR-132 than do healthy individuals. This increase is further elevated by cigarette smoking. Together, these results reveal a hitherto unrecognized mechanism by which CS could exacerbate RA and further advance understanding of the impact of environmental factors on the pathogenesis of chronic inflammatory diseases. |
| Subject: | Th17 cells Exosomes Osteogenesis Arthritis, rheumatoid Cyclooxygenase 2 Osteoclasts Tobacco use disorder |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAO - DEPARTAMENTO DE CLÍNICA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.1073/pnas.2017120118 |
| URI: | http://hdl.handle.net/1843/82039 |
| Issue Date: | 28-Dec-2020 |
| metadata.dc.url.externa: | https://www.pnas.org/doi/10.1073/pnas.2017120118?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed |
| metadata.dc.relation.ispartof: | Proceedings of the National Academy of Sciences of the United States of America |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Cigarette smoke induces miR-132 in Th17 cells that enhance osteoclastogenesis in inflammatory arthritis.pdf | 732.16 kB | Adobe PDF | View/Open |
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