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Type:	Artigo de Periódico
Title:	Covid-19 outcomes in people living with hiv: peering through the waves
Authors:	Thaís Lorenna Souzasales Lucas Emanuel Ferreira Ramos Alexandre Vargas Schwarzbold Alzira de Oliveira Jorge Ana Luiza Bahia Alves Scotton Bruno Mateus de Castro Carla Thais Cândida Alves da Silva Carolina Marques Ramos Fernando Anschau Fernando Antonio Botoni Genna Maira Santos Grizende Maíra Viana Rego Souza-silva Matheus Carvalho Alves Nogueira Polianna Delfino-pereira João Victor Baroni Neves Manuela Furtado Sacioto Vivian Costa Morais de Assis Helena Duani Neimy Ramos de Oliveira Natália da Cunha Severino Sampaio
Abstract:	Objective: To evaluate clinical characteristics and outcomes of COVID-19 patients infected with HIV, and to compare with a paired sample without HIV infection. Methods: This is a substudy of a Brazilian multicentric cohort that comprised two periods (2020 and 2021). Data was obtained through the retrospective review of medical records. Primary outcomes were admission to the intensive care unit, invasive mechanical ventilation, and death. Patients with HIV and controls were matched for age, sex, number of comorbidities, and hospital of origin using the technique of propensity score matching (up to 4:1). They were compared using the Chi-Square or Fisher’s Exact tests for categorical variables and the Wilcoxon for numerical variables. Results: Throughout the study, 17,101 COVID-19 patients were hospitalized, and 130 (0.76%) of those were infected with HIV. The median age was 54 (IQR: 43.0;64.0) years in 2020 and 53 (IQR: 46.0;63.5) years in 2021, with a predominance of females in both periods. People Living with HIV (PLHIV) and their controls showed similar prevalence for admission to the ICU and invasive mechanical ventilation requirement in the two periods, with no significant differences. In 2020, in-hospital mortality was higher in the PLHIV compared to the controls (27.9% vs. 17.7%; p = 0.049), but there was no difference in mortality between groups in 2021 (25.0% vs. 25.1%;p> 0.999).Conclusions: Our results reiterate that PLHIV were at higher risk of COVID-19 mortality in the early stages of the pandemic, however, this finding did not sustain in 2021, when the mortality rate is similar to the control group.
Subject:	COVID-19 HIV-1 Intensive Care Units Ventilators, Mechanical Mortality
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	ICX - DEPARTAMENTO DE ESTATÍSTICA MED - DEPARTAMENTO DE CLÍNICA MÉDICA MED - DEPARTAMENTO DE MEDICINA PREVENTIVA SOCIAL
Rights:	Acesso Aberto
metadata.dc.identifier.doi:	https://doi.org/10.1016/j.clinsp.2023.100223
URI:	http://hdl.handle.net/1843/82839
Issue Date:	2023
metadata.dc.url.externa:	https://www.scielo.br/j/clin/a/99YgBMXWM3tk8MF5syg5f4w/?format=pdf
metadata.dc.relation.ispartof:	Clinics
Appears in Collections:	Artigo de Periódico

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