Qualidade de vida relacionada à saúde em pacientes com lúpus eritematoso sistêmico atendidas no serviço de reumatologia do Hospital das Clínicas/UFMG: impacto da obesidade

Abstract

Systemic lupus erythematosus (SLE) is an inflammatory autoimmune multisystemic disease frequently associated with obesity, which, in turn increases chronic inflammation. Very little is known on the association between LES, obesity and health-related quality of life (HRQoL) among patients with this disease. Therefore, the objective of the present study was to evaluate the HRQoL among SLE patients and, to assess if obesity impacts on HRQoL, as well as to evaluate eating habits of these patients. Women with ages between 18 and 60 years and, diagnosis of SLE (ACR criteria 1982/97) were assessed at the Service of Rheumatology of Hospital das Clínicas, Universidade Federal de Minas Gerais. The control group consisted of women, with the same age, without any diagnosis of inflammatory or infectious disease. Obesity was assessed by body mass index (BMI), waist circumference (WC) and bioelectrical impedance analysis (BIA). To evaluate the HRQoL, the Short Form Health Survey 36 (SF-36v1) questionnaire was used. 188 women with SLE and 69 controls were included. Obesity was seen in 28.1%, 26.3%, and 49.7% of patients according to BMI, BIA and WC, respectively. Similarly, 34.7%, 42.0% and 48.6% of control women were classified as obese by BMI, BIA, WC, respectively. There was no significant difference in obesity rates between patients and controls. Patients and controls presented witch inadequate eating habits. HRQoL was worse in patients with SLE when considering Functional Capacity, Physical Aspects, General Health, Emotional Aspects and Mental Health. Among SLE patients, obese had significantly worse Functional Capacity. Age at diagnosis, SLICC were the variables associated with worse escores on the CoF. These results reinforce the need to stimulate weight loss, in order to improve physical health and functional capacity in patients with SLE.