Efeito do tempo da compressão mecânica extrínseca após escleroterapia em veias de orelhas de coelhos

Abstract

Introduction: The compression therapy is recognized as effective in the treatment of venous and lymphatic diseases. Despite the scientific evidence on some clinical indications, there is still much to be investigated. Objectives: To investigate whether venous compression time of 120 hours after sclerotherapy is sufficient to prevent blood reperfusion in the veins treated after removal of the compression method; to assess whether there is any relation between the intensity of inflammation in the venous wall and adjacent tissues and the size of venous thrombus; investigate whether the intensity of the inflammatory process post-sclerotherapy varies with time compression; check for the relation between the presence of hemosiderin in tissues adjacent to the sclerotic vessel and clot in the venous lumen. Method: 28 malerabbits from Oryctolagus cuniculus species, randomly assigned to four groups of seven animals (groups: 0, 24, 72 and 120) were used. All animals were given 0.25 ml of polidocanol 1% and, as control, 0.25 ml of sodium chloride 0.9% in the dorsal marginal vein of the right and left ears, respectively. Mechanical compression was performed in extravenous section of 1.5 to 2 cm of the infused vein, except in group0. The compression time ranged from 0 to 120 hours in different groups. Anatomicpathology study of section was made of the right and left dorsal marginal vein of all animals. Results: along with the different times of compression, there were no significant differences in the degree of thrombosis, and in the intensity of inflammation of the vessel and surrounding tissue in both ears, including on the control group. There was a significantly positive correlation between the intensity of inflammatory process and size of the thrombus, as well as between the occurrence of thrombi and hemosiderin. Conclusion: the time up to 120 hours of compression is not sufficient to prevent reperfusion after decompression. The intensity of the inflammatory process in the vessel and surrounding tissue is related to the size of the thrombus and has no relation with time compression. The presence of hemosiderin in tissues adjacent to the vessel that received intravenous injection is related to thepresence of clot in the vessel lumen.