Il-6 and type 1 diabetes mellitus: t cell responses and increase in il-6 receptor surface expression
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Universidade Federal de Minas Gerais
Descrição
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Artigo de periódico
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Membros da banca
Resumo
Type 1 diabetes mellitus (T1D) is an autoimmune disease
characterized by beta cell destruction, associated with
cellular infiltration and inflammatory responses in the islets
of Langerhans. The cellular components of this infiltrate
include monocytes, macrophages, CD4+ and CD8+ T cells,
and the balance between Th1 and Th2 cells is crucial in the
pathogenesis of this disease.
Cytokines play important role in the development and
activation of immune cells, since they act as cell-signaling
molecules, especially in autoimmune diseases, including
T1D. Moreover, cytokines may serve as additional
biomarkers of T1D. Cytokines may also provide valuable
information about the pathways involved in the regulation
of T1D processes. Interleukin-6 (IL-6), a multifunctional
cytokine, is secreted by T cells and macrophages to
stimulate immune response during inflammation
and infection. Indeed, this cytokine is involved in the
inflammatory response associated with insulin-resistant
states.
Abstract
Assunto
Diabetes mellitus tipo 1
Palavras-chave
Type 1 diabetes mellitus, IL-6
Citação
Curso
Endereço externo
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253293/pdf/atm-05-01-16.pdf