Il-6 and type 1 diabetes mellitus: t cell responses and increase in il-6 receptor surface expression

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dc.creatorKarina Braga Gomes Borges
dc.date.accessioned2021-07-19T22:12:13Z
dc.date.accessioned2025-09-08T23:02:26Z
dc.date.available2021-07-19T22:12:13Z
dc.date.issued2017
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.format.mimetypepdf
dc.identifier.doi10.21037/atm.2016.12.74
dc.identifier.issn23055839
dc.identifier.urihttps://hdl.handle.net/1843/36787
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofAnnals of Translational Medicine
dc.rightsAcesso Aberto
dc.subjectDiabetes mellitus tipo 1
dc.subject.otherType 1 diabetes mellitus
dc.subject.otherIL-6
dc.titleIl-6 and type 1 diabetes mellitus: t cell responses and increase in il-6 receptor surface expression
dc.typeArtigo de periódico
local.citation.epage16
local.citation.issue1
local.citation.spage16
local.citation.volume5
local.description.resumoType 1 diabetes mellitus (T1D) is an autoimmune disease characterized by beta cell destruction, associated with cellular infiltration and inflammatory responses in the islets of Langerhans. The cellular components of this infiltrate include monocytes, macrophages, CD4+ and CD8+ T cells, and the balance between Th1 and Th2 cells is crucial in the pathogenesis of this disease. Cytokines play important role in the development and activation of immune cells, since they act as cell-signaling molecules, especially in autoimmune diseases, including T1D. Moreover, cytokines may serve as additional biomarkers of T1D. Cytokines may also provide valuable information about the pathways involved in the regulation of T1D processes. Interleukin-6 (IL-6), a multifunctional cytokine, is secreted by T cells and macrophages to stimulate immune response during inflammation and infection. Indeed, this cytokine is involved in the inflammatory response associated with insulin-resistant states.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.initialsUFMG
local.url.externahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253293/pdf/atm-05-01-16.pdf

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