Plasma levels of tumor necrosis factor superfamily molecules are increased in bipolar disorder
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Membros da banca
Resumo
Objective: Patients with bipolar disorder (BD) exhibit peripheral low-grade inflammation. The aim of the current study was to investigate the involvement of hitherto unexplored components of the tumor necrosis factor (TNF) superfamily in BD.Methods: Eighty patients with type I BD and 50 healthy controls matched for age and gender were enrolled in this study. All subjects were assessed with the Mini-Plus to evaluate psychiatric comorbidities; the Young Mania Rating Scale and the HamiltonDepression Rating Scale to evaluate manic and depressive symptoms severity, respectively. TNF superfamily molecules (TNF, TNF-related weak inducer of apoptosis [TWEAK], TNF-related apoptosis-inducing ligand [TRAIL], soluble TNF receptor type1 [sTNFR1], and soluble TNF receptor type 2 [sTNFR2]) levels were measured by ELISA.Results: Patients with BD, regardless of mood state, presented increased plasma levels of sTNFR1 and TWEAK in comparison with controls. Conclusion: These findings corroborate the view that TNF superfamily may play a role in BD pathophysiology.
Abstract
Assunto
Transtorno Bipolar, Receptor de TWEAK, Receptores do Ligante Indutor de Apoptose Relacionado a TNF
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Bipolar disorder, TWEAK, sTNFR, TRAIL
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https://www.cpn.or.kr/journal/view.html?doi=10.9758/cpn.2017.15.3.269