Plasma levels of tumor necrosis factor superfamily molecules are increased in bipolar disorder

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dc.creatorIzabela Guimarães Barbosa
dc.creatorGabriela Neves Vaz
dc.creatorNatalia Pessoa Rocha
dc.creatorRodrigo Machado-vieira
dc.creatorMarcio Rogerio Diniz Ventura
dc.creatorRodrigo b. Huguet
dc.creatorMoises e. Bauer
dc.creatorMichael Berk
dc.creatorAntônio l. Teixeira
dc.date.accessioned2023-07-14T22:56:06Z
dc.date.accessioned2025-09-08T23:54:42Z
dc.date.available2023-07-14T22:56:06Z
dc.date.issued2017-05-09
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.9758/cpn.2017.15.3.269
dc.identifier.issn17381088
dc.identifier.urihttps://hdl.handle.net/1843/56341
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofClinical Psychopharmacology and Neuroscience
dc.rightsAcesso Aberto
dc.subjectTranstorno Bipolar
dc.subjectReceptor de TWEAK
dc.subjectReceptores do Ligante Indutor de Apoptose Relacionado a TNF
dc.subject.otherBipolar disorder
dc.subject.otherTWEAK
dc.subject.othersTNFR
dc.subject.otherTRAIL
dc.titlePlasma levels of tumor necrosis factor superfamily molecules are increased in bipolar disorder
dc.typeArtigo de periódico
local.citation.epage275
local.citation.issue3
local.citation.spage269
local.citation.volume15
local.description.resumoObjective: Patients with bipolar disorder (BD) exhibit peripheral low-grade inflammation. The aim of the current study was to investigate the involvement of hitherto unexplored components of the tumor necrosis factor (TNF) superfamily in BD.Methods: Eighty patients with type I BD and 50 healthy controls matched for age and gender were enrolled in this study. All subjects were assessed with the Mini-Plus to evaluate psychiatric comorbidities; the Young Mania Rating Scale and the HamiltonDepression Rating Scale to evaluate manic and depressive symptoms severity, respectively. TNF superfamily molecules (TNF, TNF-related weak inducer of apoptosis [TWEAK], TNF-related apoptosis-inducing ligand [TRAIL], soluble TNF receptor type1 [sTNFR1], and soluble TNF receptor type 2 [sTNFR2]) levels were measured by ELISA.Results: Patients with BD, regardless of mood state, presented increased plasma levels of sTNFR1 and TWEAK in comparison with controls. Conclusion: These findings corroborate the view that TNF superfamily may play a role in BD pathophysiology.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTAL
local.publisher.initialsUFMG
local.url.externahttps://www.cpn.or.kr/journal/view.html?doi=10.9758/cpn.2017.15.3.269

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