Interactions of natural products and antimicrobial drugs: investigations of a dark matter in chemistry
Carregando...
Data
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Federal de Minas Gerais
Descrição
Tipo
Artigo de periódico
Título alternativo
Primeiro orientador
Membros da banca
Resumo
Bacterial infectious diseases are each time more difficult to manage due to the limited options of antimicrobial drugs and due to the
multidrug resistance profile of pathogenic strains. Several works on natural products of vegetable sources have provided evidence of the antimicrobial potential of different phytomolecules such as flavonoids. Thus, they represent an important strategy to overcome the
microbial resistance scenario. Beyond the use of natural products alone in popular medicine, they are commonly combined to synthetic
drugs of different pharmacological groups such as antimicrobials in several ways, including interactions with industrially-manufactured
or artisanally prepared phytotherapics, nutritional supplements, food, juices, and teas. Such interactions are often ignored in the clinical
context. Synergistic interactions can improve treatment outcomes, however, enough evidences of efficacy and safety must be provided
before being clinically used. Here, interactions of natural products with antimicrobial drugs against bacterial pathogens are discussed,
aiming to provide contributions for advancements on the field towards a safe clinical use of such combinations. The data discussed here might open doors for improvements on phytotherapy for infectious bacterial diseases.
Abstract
Assunto
Produtos naturais, Interações, Produtos com Ação Antimicrobiana
Palavras-chave
Natural Products, Interactions, Antimicrobial
Citação
Departamento
Curso
Endereço externo
https://biointerfaceresearch.com/?page_id=2421