Preliminary data of the antipancreatic tumor efficacy and toxicity of long-circulating and ph-sensitive liposomes containing cisplatin
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Data
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Federal de Minas Gerais
Descrição
Tipo
Artigo de periódico
Título alternativo
Primeiro orientador
Membros da banca
Resumo
Purpose
Pancreatic cancer is the fourth most common cause of cancer-related death in the USA. This is mainly because of the chemoresistance of this type of tumor; thus, the development of novel therapeutic modalities is needed.
Methods
Long-circulating and pH-sensitive liposomes containing cisplatin (SpHL-CDDP) were administered systemically into pancreatic tumor-bearing mice for a period of 14 days. The antitumor efficacy and toxicity of this new treatment method on the basis of cisplatin-loaded liposomes was compared with the classical free-CDDP method. 99mTc-HYNIC-βAla-bombesin(7–14) tumor uptake and histopathologic findings were used to monitor and compare the two treatment modalities.
Results
The antitumor activity of SpHL-CDDP treatment was shown by (a) decrease in tumor volume, (b) development of tumor necrotic areas, and (c) decrease in 99mTc-HYNIC-βAla-bombesin(7–14) tumor uptake. Toxicity was evaluated by the development of inflammation and necrotic areas in the kidneys, liver, spleen, and intestine: toxic effects were greater with free-CDDP than SpHL-CDDP.
Conclusion
SpHL-CDDP showed significant antitumor activity in pancreatic cancer-bearing mice, with lower toxicity in comparison with free-CDDP.
Abstract
Assunto
Toxicologia, Tumor
Palavras-chave
Antitumoral efficacy, Antitumoral toxicity, Free-cisplatin, Pancreatic tumor, pH-sensitive liposome-containing cisplatin
Citação
Curso
Endereço externo
https://journals.lww.com/nuclearmedicinecomm/Abstract/2016/07000/Preliminary_data_of_the_antipancreatic_tumor.7.aspx