Preliminary data of the antipancreatic tumor efficacy and toxicity of long-circulating and ph-sensitive liposomes containing cisplatin

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dc.creatorFernanda Noal Carlesso
dc.creatorRaquel Silva Araújo
dc.creatorLeonardo Lima Fuscaldi
dc.creatorSued Eustáquio Mendes Miranda
dc.creatorDomenico Rubello
dc.creatorCláudia S. Teixeira
dc.creatorDiego Carlos dos Reis
dc.creatorElaine Amaral Leite
dc.creatorJosianne N. Silveira
dc.creatorSimone Odília Antunes Fernandes
dc.creatorGeovanni Dantas Cassali
dc.creatorMônica Cristina de Oliveira
dc.creatorPatrick M. Colletti
dc.creatorAndré Luís Branco de Barros
dc.creatorValbert Nascimento Cardoso
dc.date.accessioned2022-02-24T00:22:57Z
dc.date.accessioned2025-09-08T23:22:40Z
dc.date.available2022-02-24T00:22:57Z
dc.date.issued2016
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doi10.1097/mnm.0000000000000505
dc.identifier.issn01433636
dc.identifier.urihttps://hdl.handle.net/1843/39632
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofNuclear Medicine Communications
dc.rightsAcesso Restrito
dc.subjectToxicologia
dc.subjectTumor
dc.subject.otherAntitumoral efficacy
dc.subject.otherAntitumoral toxicity
dc.subject.otherFree-cisplatin
dc.subject.otherPancreatic tumor
dc.subject.otherpH-sensitive liposome-containing cisplatin
dc.titlePreliminary data of the antipancreatic tumor efficacy and toxicity of long-circulating and ph-sensitive liposomes containing cisplatin
dc.typeArtigo de periódico
local.citation.epage734
local.citation.issue7
local.citation.spage727
local.citation.volume37
local.description.resumoPurpose Pancreatic cancer is the fourth most common cause of cancer-related death in the USA. This is mainly because of the chemoresistance of this type of tumor; thus, the development of novel therapeutic modalities is needed. Methods Long-circulating and pH-sensitive liposomes containing cisplatin (SpHL-CDDP) were administered systemically into pancreatic tumor-bearing mice for a period of 14 days. The antitumor efficacy and toxicity of this new treatment method on the basis of cisplatin-loaded liposomes was compared with the classical free-CDDP method. 99mTc-HYNIC-βAla-bombesin(7–14) tumor uptake and histopathologic findings were used to monitor and compare the two treatment modalities. Results The antitumor activity of SpHL-CDDP treatment was shown by (a) decrease in tumor volume, (b) development of tumor necrotic areas, and (c) decrease in 99mTc-HYNIC-βAla-bombesin(7–14) tumor uptake. Toxicity was evaluated by the development of inflammation and necrotic areas in the kidneys, liver, spleen, and intestine: toxic effects were greater with free-CDDP than SpHL-CDDP. Conclusion SpHL-CDDP showed significant antitumor activity in pancreatic cancer-bearing mice, with lower toxicity in comparison with free-CDDP.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOS
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://journals.lww.com/nuclearmedicinecomm/Abstract/2016/07000/Preliminary_data_of_the_antipancreatic_tumor.7.aspx

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