Impact of non-surgical periodontal treatment on serum TNF-α levels in individuals with type 2 Diabetes: a systematic review and meta-analysis
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Membros da banca
Resumo
Objective
The objective of this systematic review and meta-analysis was to search for scientific evidence on the impact of non-surgical periodontal therapy on tumor necrosis factor alpha (TNF-α) in type 2 diabetics.
Methods
The Preferred Reporting Items for Systematic Reviews and Meta‐Analyses statement has been followed. The study was registered (CRD42020192790) in the International prospective register of systematic reviews. Searches were conducted in five databases. Restrictions on publication date were not imposed in anyway. The studies reporting the serum TNF-α levels of individuals with type 2 diabetes mellitus (DM) before and after non-surgical periodontal therapy were included. Studies’ selection, extraction of data and risk of bias assessment were performed in duplicate. Consensus was achieved. Meta‐analysis was carried out. The 95% confidence interval and odds ratio were provided.
Results
Six hundred and twenty-three references were retrieved and eighteen studies were included. Meta-analysis demonstrated that the serum levels of TNF-α in individuals with type 2 DM decreased six months after non-surgical periodontal therapy (mean difference = -1.90, confidence interval = -3.05–-0.74). Included studies presented low risk of bias.
Conclusion
Non-surgical periodontal therapy has an impact on serum TNF-α levels at six months in type 2 DM patients.
Abstract
Assunto
Diabetes Mellitus, Type 2, Periodontitis, Tumor necrosis factor-alpha, Therapeutics, Network meta-analysis, Systematic review
Palavras-chave
revisão sistemática acesso restrito fao clínica e fao odontopediatria busca dia 21/06/2024Impact of non-surgical periodontal treatment on serum TNF-α levels in individuals with type 2 Diabetes: a systematic review and meta-analysis, TNF- alfa key words Diabetes mellitus, Type 2 Tumor necrosis factor-alpha Periodontitis, diabetes type 2, periodontal treatment Journal of Evidence Based Dental Practice
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Endereço externo
https://www.sciencedirect.com/science/article/pii/S153233822100021X