Impact of non-surgical periodontal treatment on serum TNF-α levels in individuals with type 2 Diabetes: a systematic review and meta-analysis

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dc.creatorRafael Paschoal Esteves Lima
dc.creatorAndressa Rafaela Silva Atanazio
dc.creatorFernando de Oliveira Costa
dc.creatorFabiano Araújo Cunha
dc.creatorLucas Guimarães Abreu
dc.date.accessioned2024-06-24T17:57:19Z
dc.date.accessioned2025-09-09T00:28:11Z
dc.date.available2024-06-24T17:57:19Z
dc.date.issued2021-06
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.jebdp.2021.101546
dc.identifier.issn1532-3390
dc.identifier.urihttps://hdl.handle.net/1843/69366
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Evidence Based Dental Practice
dc.rightsAcesso Restrito
dc.subjectDiabetes Mellitus, Type 2
dc.subjectPeriodontitis
dc.subjectTumor necrosis factor-alpha
dc.subjectTherapeutics
dc.subjectNetwork meta-analysis
dc.subjectSystematic review
dc.subject.otherrevisão sistemática acesso restrito fao clínica e fao odontopediatria busca dia 21/06/2024Impact of non-surgical periodontal treatment on serum TNF-α levels in individuals with type 2 Diabetes: a systematic review and meta-analysis
dc.subject.otherTNF- alfa key words Diabetes mellitus, Type 2 Tumor necrosis factor-alpha Periodontitis
dc.subject.otherdiabetes type 2
dc.subject.otherperiodontal treatment Journal of Evidence Based Dental Practice
dc.titleImpact of non-surgical periodontal treatment on serum TNF-α levels in individuals with type 2 Diabetes: a systematic review and meta-analysis
dc.typeArtigo de periódico
local.citation.epageJournal of Evidence Based Dental Practice
local.citation.issue2
local.citation.spage101546
local.citation.volume21
local.description.resumoObjective The objective of this systematic review and meta-analysis was to search for scientific evidence on the impact of non-surgical periodontal therapy on tumor necrosis factor alpha (TNF-α) in type 2 diabetics. Methods The Preferred Reporting Items for Systematic Reviews and Meta‐Analyses statement has been followed. The study was registered (CRD42020192790) in the International prospective register of systematic reviews. Searches were conducted in five databases. Restrictions on publication date were not imposed in anyway. The studies reporting the serum TNF-α levels of individuals with type 2 diabetes mellitus (DM) before and after non-surgical periodontal therapy were included. Studies’ selection, extraction of data and risk of bias assessment were performed in duplicate. Consensus was achieved. Meta‐analysis was carried out. The 95% confidence interval and odds ratio were provided. Results Six hundred and twenty-three references were retrieved and eighteen studies were included. Meta-analysis demonstrated that the serum levels of TNF-α in individuals with type 2 DM decreased six months after non-surgical periodontal therapy (mean difference = -1.90, confidence interval = -3.05–-0.74). Included studies presented low risk of bias. Conclusion Non-surgical periodontal therapy has an impact on serum TNF-α levels at six months in type 2 DM patients.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S153233822100021X

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