Blood neuron cell-derived microparticles as potential biomarkers in Alzheimer’s disease
Carregando...
Data
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Federal de Minas Gerais
Descrição
Tipo
Artigo de periódico
Título alternativo
Primeiro orientador
Membros da banca
Resumo
Alzheimer’s disease (AD) is the most frequent cause of dementia, associated with a significant and progressive loss of both cognitive and functional performance [1].Microparticles (MPs) are microvesicles, ranging from 0.1 to 1 µm, released from the cell membrane during its activation and apoptosis. They are involved in cell-cell communication transferring cyto/nuclear proteins, DNA, mRNA and miRNA [2, 3]. Considering that MPs are involved in neuroinflammation and hemostasis, and that levels of several vascular and inflammatory factors were reported to be increased in patients with AD [4], we hypothesized that plasmatic MPs levels (platelet, leukocyte, endothe lial, neuron cell-derived MPs and MPs that express tissue factor [TF]) may be potential biomarkers to AD diagnosis.
Abstract
Assunto
Doença de Alzheimer, Disfunção Cognitiva, Biomarcadores
Palavras-chave
Alzheimer’s disease, Cognitive Dysfunction, Biomarkers
Citação
Curso
Endereço externo
https://www.degruyter.com/document/doi/10.1515/cclm-2018-0483/html