Peripheral levels of angiotensins are associated with depressive symptoms in parkinson's disease
Carregando...
Data
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Federal de Minas Gerais
Descrição
Tipo
Artigo de periódico
Título alternativo
Primeiro orientador
Membros da banca
Resumo
Background: The pathogenesis of PD remains elusive. The renin-angiotensin-system (RAS) has recently been implicated in the degeneration of dopaminergic neurons. This study aimed to compare plasma levels of components of the RAS of individuals with PD with controls. We also investigated the association between these circulating markers and motor, depressive and cognitive parameters.
Methods: Thirty PD patients and twenty controls were subjected to clinical evaluation, including cognitive and depressive symptoms assessment. Plasma levels of Angiotensin (Ang) I, Ang II, Ang- (1–7), angiotensin converting enzyme (ACE) and ACE2 were measured by Enzyme-Linked Immunosorbent Assay (ELISA). Results: PD patients presented lower plasma levels of Ang I, Ang II and Ang- (1–7) than control individuals. Among PD patients, lower circulating levels of angiotensins were associated with increased severity of depressive symptoms. Conclusions: This is the first study showing that peripheral levels of RAS components are changed in PD and as sociated with depressive symptoms.
Abstract
Assunto
Doença de Parkinson, Sistema Renina-Angiotensina, Depressão, Cognição
Palavras-chave
Parkinson's disease, Renin-angiotensin system, Non-motor symptoms, Depression, Cognition
Citação
Curso
Endereço externo
https://www.jns-journal.com/article/S0022-510X(16)30446-4/fulltext