Peripheral levels of angiotensins are associated with depressive symptoms in parkinson's disease

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dc.creatorNatalia Pessoarocha
dc.creatorAntonio Lucio Teixeira Junior
dc.creatorPaula Luciana Scalzo
dc.creatorIzabela Guimarães Barbosa
dc.creatorSalvina Maria de Campos-carli
dc.creatorLívia Duarte Tavares
dc.creatorMariana Soares de Souza
dc.creatorPaulo Pereira Christo
dc.creatorHelton José Reis
dc.creatorAna Cristina Simões e Silva
dc.date.accessioned2023-07-14T20:52:46Z
dc.date.accessioned2025-09-09T01:23:59Z
dc.date.available2023-07-14T20:52:46Z
dc.date.issued2016-07-14
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.jns.2016.07.031
dc.identifier.issn0022510X
dc.identifier.urihttps://hdl.handle.net/1843/56310
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of the Neurological Sciences
dc.rightsAcesso Restrito
dc.subjectDoença de Parkinson
dc.subjectSistema Renina-Angiotensina
dc.subjectDepressão
dc.subjectCognição
dc.subject.otherParkinson's disease
dc.subject.otherRenin-angiotensin system
dc.subject.otherNon-motor symptoms
dc.subject.otherDepression
dc.subject.otherCognition
dc.titlePeripheral levels of angiotensins are associated with depressive symptoms in parkinson's disease
dc.typeArtigo de periódico
local.citation.epage239
local.citation.spage235
local.citation.volume368
local.description.resumoBackground: The pathogenesis of PD remains elusive. The renin-angiotensin-system (RAS) has recently been implicated in the degeneration of dopaminergic neurons. This study aimed to compare plasma levels of components of the RAS of individuals with PD with controls. We also investigated the association between these circulating markers and motor, depressive and cognitive parameters. Methods: Thirty PD patients and twenty controls were subjected to clinical evaluation, including cognitive and depressive symptoms assessment. Plasma levels of Angiotensin (Ang) I, Ang II, Ang- (1–7), angiotensin converting enzyme (ACE) and ACE2 were measured by Enzyme-Linked Immunosorbent Assay (ELISA). Results: PD patients presented lower plasma levels of Ang I, Ang II and Ang- (1–7) than control individuals. Among PD patients, lower circulating levels of angiotensins were associated with increased severity of depressive symptoms. Conclusions: This is the first study showing that peripheral levels of RAS components are changed in PD and as sociated with depressive symptoms.
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIA
local.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTAL
local.publisher.initialsUFMG
local.url.externahttps://www.jns-journal.com/article/S0022-510X(16)30446-4/fulltext

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