Potential role of adult hippocampal neurogenesis in traumatic brain injury
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Resumo
Traumatic brain injury (TBI) is a serious cause of disability and death among young and adult individuals, displaying complex pathophysiology including cellular and molecular mechanisms that are not fully elucidated. Many experimental and clinical studies
investigated the potential relationship between TBI and the process by which neurons are formed in the brain, known as neurogenesis. Currently, there are no available treatments for TBI’s long-term consequences being the search for novel therapeutic targets, a
goal of highest scientific and clinical priority. Some studies evaluated the benefits of treatments aimed at improving neurogenesis in TBI. In this scenario, herein, we reviewed current pre-clinical studies that evaluated different approaches to improving neurogenesis
after TBI while achieving better cognitive outcomes, which may consist in interesting approaches for future treatments.
Abstract
Assunto
Cérebro - Ferimentos e lesões, Neurologia do desenvolvimento, Hipocampo (Cérebro), Terapêutica
Palavras-chave
Traumatic brain injury, Neurogenesis, Hippocampus, Models, Animal, Dentate gyrus, Therapeutics
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Endereço externo
https://www.eurekaselect.com/article/118144