Potential role of adult hippocampal neurogenesis in traumatic brain injury

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dc.creatorLucas Alexandre Santos Marzano
dc.creatorFabyolla Lucia Macedo de Castro
dc.creatorCaroline Amaral Machado
dc.creatorJoão Luís Vieira Monteiro de Barros
dc.creatorThiago Macedo e Cordeiro
dc.creatorAna Cristina Simões e Silva
dc.creatorAntonio Lucio Teixeira
dc.creatorAline Silva de Miranda
dc.date.accessioned2023-07-03T20:43:04Z
dc.date.accessioned2025-09-08T23:38:34Z
dc.date.available2023-07-03T20:43:04Z
dc.date.issued2022
dc.identifier.doihttp://dx.doi.org/10.2174/0929867328666210923143713
dc.identifier.issn1875-533X
dc.identifier.urihttps://hdl.handle.net/1843/55703
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofCurrent Medicinal Chemistry
dc.rightsAcesso Restrito
dc.subjectCérebro - Ferimentos e lesões
dc.subjectNeurologia do desenvolvimento
dc.subjectHipocampo (Cérebro)
dc.subjectTerapêutica
dc.subject.otherTraumatic brain injury
dc.subject.otherNeurogenesis
dc.subject.otherHippocampus
dc.subject.otherModels
dc.subject.otherAnimal
dc.subject.otherDentate gyrus
dc.subject.otherTherapeutics
dc.titlePotential role of adult hippocampal neurogenesis in traumatic brain injury
dc.typeArtigo de periódico
local.citation.epage3419
local.citation.issue19
local.citation.spage3392
local.citation.volume29
local.description.resumoTraumatic brain injury (TBI) is a serious cause of disability and death among young and adult individuals, displaying complex pathophysiology including cellular and molecular mechanisms that are not fully elucidated. Many experimental and clinical studies investigated the potential relationship between TBI and the process by which neurons are formed in the brain, known as neurogenesis. Currently, there are no available treatments for TBI’s long-term consequences being the search for novel therapeutic targets, a goal of highest scientific and clinical priority. Some studies evaluated the benefits of treatments aimed at improving neurogenesis in TBI. In this scenario, herein, we reviewed current pre-clinical studies that evaluated different approaches to improving neurogenesis after TBI while achieving better cognitive outcomes, which may consist in interesting approaches for future treatments.
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.eurekaselect.com/article/118144

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