Efficacy of different treatments for burning mouth syndrome: network meta-analysis using minimally contextualized approa
Carregando...
Data
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Federal de Minas Gerais
Descrição
Tipo
Artigo de periódico
Título alternativo
Primeiro orientador
Membros da banca
Resumo
Objective: This systematic review of randomized con trolled trials (RCTs) aimed to assess the effectiveness of treat ments to relieve pain caused by burning mouth syndrome (BMS).
Study Design: five databases and grey literature were
searched, and the reference lists of included studies were manu ally searched. Independent reviewers selected studies, extracted
data, and assessed risk of bias (RoB 2.0). The main outcome was
pain relief. For the network meta-analysis (NMA), four compara ble interventions were grouped into different geometries to ensure the transitivity assumption: laser, alpha lipoic acid (ALA),
phytotherapics, and anxiolytics/antidepressants. The certainty of
evidence was assessed using the GRADE approach for NMA
with GRADE minimally contextualized framework.
Results: The anxiolytic medicine (clonazepam) likely
reduces pain caused by BMS when compared to placebo (MD:
-1.97; 95% CI: -2.31; -1.64; moderate certainty). Although laser,
ALA, and phytoterapics proved to be better when compared to
placebos, the certainty was low or very low.
Conclusion: among all tested treatments, only clonaze pan is likely to reduce pain caused by BMS when compared to
placebos. Most other treatments had low and very low certainty,
mainly due to imprecision and indirectness. More RCTs compar ing treatments against placebo are encouraged to confirm the
evidence.
Abstract
Assunto
Clonazepam, Anti-anxiety agents, Phytotherapeutic drugs, Network meta-analysis, Antidepressive agents, Systematic review
Palavras-chave
Citação
Departamento
Curso
Endereço externo
https://www.sciencedirect.com/science/article/pii/S2212440323001980