Efficacy of different treatments for burning mouth syndrome: network meta-analysis using minimally contextualized approa

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dc.creatorRachel Alvarenga Brant
dc.creatorFernando Oliveira Costa
dc.creatorGustavo Henrique de Mattos Pereira
dc.creatorRafael Paschoal Esteves Lima
dc.creatorFernanda Vieira Belém
dc.creatorRicardo Santiago Gomez
dc.creatorCarolina Castro Martins
dc.date.accessioned2024-09-30T22:31:24Z
dc.date.accessioned2025-09-09T00:58:08Z
dc.date.available2024-09-30T22:31:24Z
dc.date.issued2023-07
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.oooo.2023.03.087
dc.identifier.issn2212-4411
dc.identifier.urihttps://hdl.handle.net/1843/77063
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
dc.rightsAcesso Restrito
dc.subjectClonazepam
dc.subjectAnti-anxiety agents
dc.subjectPhytotherapeutic drugs
dc.subjectNetwork meta-analysis
dc.subjectAntidepressive agents
dc.subjectSystematic review
dc.titleEfficacy of different treatments for burning mouth syndrome: network meta-analysis using minimally contextualized approa
dc.typeArtigo de periódico
local.citation.epagee37
local.citation.issue1
local.citation.spagee36
local.citation.volume136
local.description.resumoObjective: This systematic review of randomized con trolled trials (RCTs) aimed to assess the effectiveness of treat ments to relieve pain caused by burning mouth syndrome (BMS). Study Design: five databases and grey literature were searched, and the reference lists of included studies were manu ally searched. Independent reviewers selected studies, extracted data, and assessed risk of bias (RoB 2.0). The main outcome was pain relief. For the network meta-analysis (NMA), four compara ble interventions were grouped into different geometries to ensure the transitivity assumption: laser, alpha lipoic acid (ALA), phytotherapics, and anxiolytics/antidepressants. The certainty of evidence was assessed using the GRADE approach for NMA with GRADE minimally contextualized framework. Results: The anxiolytic medicine (clonazepam) likely reduces pain caused by BMS when compared to placebo (MD: -1.97; 95% CI: -2.31; -1.64; moderate certainty). Although laser, ALA, and phytoterapics proved to be better when compared to placebos, the certainty was low or very low. Conclusion: among all tested treatments, only clonaze pan is likely to reduce pain caused by BMS when compared to placebos. Most other treatments had low and very low certainty, mainly due to imprecision and indirectness. More RCTs compar ing treatments against placebo are encouraged to confirm the evidence.
local.identifier.orcidhttps://orcid.org/0000-0001-9358-2262
local.identifier.orcidhttps://orcid.org/0000-0002-7687-1238
local.identifier.orcidhttps://orcid.org/0000-0003-0176-0741
local.identifier.orcidhttps://orcid.org/0000-0003-4343-3845
local.identifier.orcidhttps://orcid.org/0000-0003-1746-2685
local.identifier.orcidhttps://orcid.org/0000-0001-8770-8009
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S2212440323001980

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