Deep brain stimulation probing performance is enhanced by pairing stimulus with epileptic seizure
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Resumo
The unpredictability of spontaneous and recurrent seizures significantly impairs the quality of life of patients
with epilepsy. Probing neural network excitability with deep brain electrical stimulation (DBS) has shown prom ising results predicting pathological shifts in brain states. This work presents a proof-of-principal that active elec troencephalographic (EEG) probing, as a seizure predictive tool, is enhanced by pairing DBS and the
electrographic seizure itself. The ictogenic model used consisted of inducing seizures by continuous intravenous
infusion of pentylenetetrazol (PTZ — 2.5 mg/ml/min) while a probing DBS was delivered to the thalamus (TH) or
amygdaloid complex to detect changes prior to seizure onset. Cortical electrophysiological recordings were per formed before, during, and after PTZ infusion. Thalamic DBS probing, but not amygdaloid, was able to predict sei zure onset without any observable proconvulsant effects. However, previously pairing amygdaloid DBS and
epileptic polyspike discharges (day-1) elicited distinct preictal cortically recorded evoked response (CRER)
(day-2) when compared with control groups that received the same amount of electrical pulses at different mo ments of the ictogenic progress at day-1. In conclusion, our results have demonstrated that the pairing strategy
potentiated the detection of an altered brain state prior to the seizure onset. The EEG probing enhancement
method opens many possibilities for both diagnosis and treatment of epilepsy
Abstract
Assunto
Cerebro, Amigdala, Sondagem
Palavras-chave
Seizure prediction, Deep brain electrical stimulation, EEG probing, Pairing strategy, Thalamus, Amygdala
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https://www.epilepsybehavior.com/article/S1525-5050(18)30512-2/fulltext