Deep brain stimulation probing performance is enhanced by pairing stimulus with epileptic seizure

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dc.creatorDanielde Castro Medeiros
dc.creatorLaio Bastos Paiva Raspante
dc.creatorFlávio Afonso Gonçalves Mourão
dc.creatorVinícius Rezende Carvalho
dc.creatorEduardo Mazoni Andrade Marçal Mendes
dc.creatorMarcio Flavio Dutra Moraes
dc.date.accessioned2023-07-26T17:02:57Z
dc.date.accessioned2025-09-08T23:14:47Z
dc.date.available2023-07-26T17:02:57Z
dc.date.issued2018
dc.identifier.doihttps://doi.org/10.1016/j.yebeh.2018.09.048
dc.identifier.issn1525-5050
dc.identifier.urihttps://hdl.handle.net/1843/57004
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofEpilepsy & Behavior
dc.rightsAcesso Aberto
dc.subjectCerebro
dc.subjectAmigdala
dc.subjectSondagem
dc.subject.otherSeizure prediction
dc.subject.otherDeep brain electrical stimulation
dc.subject.otherEEG probing
dc.subject.otherPairing strategy
dc.subject.otherThalamus
dc.subject.otherAmygdala
dc.titleDeep brain stimulation probing performance is enhanced by pairing stimulus with epileptic seizure
dc.typeArtigo de periódico
local.citation.epage387
local.citation.issueP380-387
local.citation.spage380
local.citation.volume88
local.description.resumoThe unpredictability of spontaneous and recurrent seizures significantly impairs the quality of life of patients with epilepsy. Probing neural network excitability with deep brain electrical stimulation (DBS) has shown prom ising results predicting pathological shifts in brain states. This work presents a proof-of-principal that active elec troencephalographic (EEG) probing, as a seizure predictive tool, is enhanced by pairing DBS and the electrographic seizure itself. The ictogenic model used consisted of inducing seizures by continuous intravenous infusion of pentylenetetrazol (PTZ — 2.5 mg/ml/min) while a probing DBS was delivered to the thalamus (TH) or amygdaloid complex to detect changes prior to seizure onset. Cortical electrophysiological recordings were per formed before, during, and after PTZ infusion. Thalamic DBS probing, but not amygdaloid, was able to predict sei zure onset without any observable proconvulsant effects. However, previously pairing amygdaloid DBS and epileptic polyspike discharges (day-1) elicited distinct preictal cortically recorded evoked response (CRER) (day-2) when compared with control groups that received the same amount of electrical pulses at different mo ments of the ictogenic progress at day-1. In conclusion, our results have demonstrated that the pairing strategy potentiated the detection of an altered brain state prior to the seizure onset. The EEG probing enhancement method opens many possibilities for both diagnosis and treatment of epilepsy
local.identifier.orcidhttps://orcid.org/0000-0003-4289-2580
local.identifier.orcidhttps://orcid.org/0000-0002-4519-3585
local.identifier.orcidhttps://orcid.org/0000-0003-1821-1634
local.identifier.orcidhttps://orcid.org/0000-0002-3267-3862
local.identifier.orcidhttps://orcid.org/0000-0002-1053-4693
local.publisher.countryBrasil
local.publisher.departmentENG - DEPARTAMENTO DE ENGENHARIA ELETRÔNICA
local.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
local.publisher.initialsUFMG
local.url.externahttps://www.epilepsybehavior.com/article/S1525-5050(18)30512-2/fulltext

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