The usefulness of short-term high-fat/high salt diet as a model of metabolic syndrome in mice

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dc.creatorLeônidas das Graças Mendes Júnior
dc.creatorLeandro Ceotto Freitas Lima
dc.creatorJanaína Ribeiro Oliveira
dc.creatorMarcos de Abreu Melo
dc.creatorJohn David Feltenberger
dc.creatorIgor Viana Brandi
dc.creatorBruna Mara Aparecida Carvalho
dc.creatorAndré Luiz Sena Guimarães
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorCarlos Eduardo Mendes D'Angelis
dc.creatorMaria José Campagnole Santos
dc.creatorRobson Augusto Souza Santos
dc.creatorValdir Andrade Braga
dc.creatorSérgio Henrique Sousa Santos
dc.date.accessioned2022-08-24T13:33:17Z
dc.date.accessioned2025-09-08T23:55:30Z
dc.date.available2022-08-24T13:33:17Z
dc.date.issued2018-09-15
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1016/j.lfs.2018.08.034
dc.identifier.issn0024-3205
dc.identifier.urihttps://hdl.handle.net/1843/44508
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofLife Sciences
dc.rightsAcesso Aberto
dc.subjectSíndrome metabólica
dc.subjectObesidade
dc.subjectMiocárdio - Doenças
dc.subjectDiabetes
dc.titleThe usefulness of short-term high-fat/high salt diet as a model of metabolic syndrome in mice
dc.typeArtigo de periódico
local.citation.epage348
local.citation.spage341
local.citation.volume209
local.description.resumoDiabetic cardiomyopathy (DC) describes diabetes-associated changes in the structure and function of myocardium that are not directly linked to other factors such as hypertension. Currently there are some models of DC; however, they take a large time period to mimic key features. In the present study, we investigated the effects of a short-term high-fat/high salt diet (HFHS) treatment on myocardial function and structure, and vascular reactivity in C57BL/6 male mice. After 14 weeks HFHS induced hypertension (MAP = 144.95 ± 16.13 vs 92.90 ± 18.95 mm Hg), low glucose tolerance (AUC = 1049.01 ± 74.79 vs 710.50 ± 52.57 a.u.), decreased insulin sensitivity (AUC = 429.83 ± 35.22 vs 313.67 ± 19.55 a.u.) and increased adiposity (epididymal fat weight 0.96 ± 0.10 vs 0.59 ± 0.06 OW/BW × 102), aspects present in metabolic syndrome. Cardiac evaluation showed diastolic dysfunction (E/A ratio = 1.20 vs 1.90 u.a.) and cardiomyocyte hypertrophy (cardiomyocyte area = 502.82 ± 31.46 vs 385.58 ± 22.11 μm2). Lastly, vascular reactivity was impaired with higher contractile response (136.10 ± 3.49 vs 120.37 ± 5.43%) and lower response to endothelium-dependent vasorelaxation (74.01 ± 4.35 vs 104.84 ± 3.57%). In addition, the diet was able to induce an inward coronary remodeling (vascular total area: SCNS 6185 ± 800.6 vs HFHS 4085 ± 213.7 μm2). Therefore, we conclude that HFHS short-term treatment was able to induce metabolic syndrome-like state, cardiomyopathy and vascular injury working as an important tool to study cardiometabolic diseases.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S002432051830479X?via%3Dihub#!

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