Preemptive effect of dexamethasone in third-molar surgery: a meta-analysis
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Membros da banca
Resumo
The aim of the present study was to assess the effectiveness of preemptive dexamethasone in surgery of the lower third molars and to compare it with other oral anti-inflammatories. An electronic search was conducted for preemptive effects related to lower third-molar surgery in 3 separate databases. The variables pain, swelling, and trismus were assessed. Meta-analysis was used to calculate the pooled effect measures for mean and standard deviation values (95% confidence interval [CI]). Seven split-mouth clinical trials were selected. Two studies were included in the meta-analysis. Three studies showed a low risk of bias; 2 studies exhibited a moderate risk and 2 a high risk of bias. Dexamethasone was better than nonsteroidal anti-inflammatories for preemptive effectiveness. Meta-analysis for swelling confirmed better results for dexamethasone than for methylprednisolone after 2 days (95% CI = −1.28 to −0.38), 4 days (95% CI = −1.65 to −0.71), 7 days (95% CI = −1.42 to −0.71), and overall (95% CI = −1.25 to −0.72). Dexamethasone was better than methylprednisolone for mouth opening after 4 days (95% CI = 0.18 to 1.07). There is insufficient evidence through meta-analysis to conclude that dexamethasone is better than other nonsteroidal anti-inflammatories or methylprednisolone as a preemptive analgesic. The results of this meta-analysis suggest that dexamethasone is more effective than methylprednisolone for swelling and trismus.
Abstract
Assunto
Molar, third, Surgery, oral, Dexamethasone, Meta-analysis
Palavras-chave
Molar, third, Surgery, oral, Dexamethasone, Meta-analysis
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https://anesthesiaprogress.kglmeridian.com/view/journals/anpr/64/3/article-p136.xml