Preemptive effect of dexamethasone in third-molar surgery: a meta-analysis

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dc.creatorSaulo Gabriel Moreira Falci
dc.creatorThiago César Lima
dc.creatorCarolina de Castro Martins
dc.creatorCássio Roberto Rocha dos Santos
dc.creatorMarcos Luciano Pimenta Pinheiro
dc.date.accessioned2024-01-24T17:39:41Z
dc.date.accessioned2025-09-08T23:49:42Z
dc.date.available2024-01-24T17:39:41Z
dc.date.issued2017
dc.identifier.doihttps://doi.org/10.2344/anpr-64-05-08
dc.identifier.issn1878-7177
dc.identifier.urihttps://hdl.handle.net/1843/63288
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofAnesthesia Progress
dc.rightsAcesso Restrito
dc.subjectMolar, third
dc.subjectSurgery, oral
dc.subjectDexamethasone
dc.subjectMeta-analysis
dc.subject.otherMolar, third
dc.subject.otherSurgery, oral
dc.subject.otherDexamethasone
dc.subject.otherMeta-analysis
dc.titlePreemptive effect of dexamethasone in third-molar surgery: a meta-analysis
dc.typeArtigo de periódico
local.citation.epage143
local.citation.issue3
local.citation.spage136
local.citation.volume64
local.description.resumoThe aim of the present study was to assess the effectiveness of preemptive dexamethasone in surgery of the lower third molars and to compare it with other oral anti-inflammatories. An electronic search was conducted for preemptive effects related to lower third-molar surgery in 3 separate databases. The variables pain, swelling, and trismus were assessed. Meta-analysis was used to calculate the pooled effect measures for mean and standard deviation values (95% confidence interval [CI]). Seven split-mouth clinical trials were selected. Two studies were included in the meta-analysis. Three studies showed a low risk of bias; 2 studies exhibited a moderate risk and 2 a high risk of bias. Dexamethasone was better than nonsteroidal anti-inflammatories for preemptive effectiveness. Meta-analysis for swelling confirmed better results for dexamethasone than for methylprednisolone after 2 days (95% CI = −1.28 to −0.38), 4 days (95% CI = −1.65 to −0.71), 7 days (95% CI = −1.42 to −0.71), and overall (95% CI = −1.25 to −0.72). Dexamethasone was better than methylprednisolone for mouth opening after 4 days (95% CI = 0.18 to 1.07). There is insufficient evidence through meta-analysis to conclude that dexamethasone is better than other nonsteroidal anti-inflammatories or methylprednisolone as a preemptive analgesic. The results of this meta-analysis suggest that dexamethasone is more effective than methylprednisolone for swelling and trismus.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIA
local.publisher.initialsUFMG
local.url.externahttps://anesthesiaprogress.kglmeridian.com/view/journals/anpr/64/3/article-p136.xml

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