Biocompatibility and immunohistochemical evaluation of a new calcium silicate-based cement, bio-c pulpo

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dc.creatorLeopoldo Cosme Silva
dc.creatorJoão Eduardo Gomes-Filho
dc.creatorFrancine Benetti
dc.creatorDal-Fabbro
dc.creatorVivien Thiemy Sakai
dc.creatorLuciano Tavarez Angelo Cintra
dc.creatorEdilson Ervolino
dc.creatorNaiana Viana Viola
dc.date.accessioned2022-09-30T18:43:50Z
dc.date.accessioned2025-09-08T23:28:54Z
dc.date.available2022-09-30T18:43:50Z
dc.date.issued2018-12-04
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1111/iej.13052
dc.identifier.issn01432885
dc.identifier.urihttps://hdl.handle.net/1843/45818
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofInternational Endodontic Journal
dc.rightsAcesso Restrito
dc.subjectOsteocalcin
dc.subjectOsteopontin
dc.subjectMaterials testing
dc.subjectPulpotomy
dc.subject.otherBiocompatibility
dc.subject.otherBone sialoprotein
dc.subject.otherOsteocalcin
dc.subject.otherOsteopontin
dc.subject.otherpulpotomy
dc.titleBiocompatibility and immunohistochemical evaluation of a new calcium silicate-based cement, bio-c pulpo
dc.typeArtigo de periódico
local.citation.epage700
local.citation.issue05
local.citation.spage689
local.citation.volume52
local.description.resumoAimTo evaluate the inflammatory response andability to induce mineral deposition through histologi-cal and immunohistochemical analysis for osteocalcin(OCN), osteopontin (OPN) and bone sialoprotein (BSP)of a new calcium silicate-based cement, Bio-C Pulpo(Angelus), compared to white mineral trioxide aggre-gate (White MTA-Ang) (Angelus).MethodologyPolyethylene tubes containing Bio-CPulpo and White MTA-Ang as well as empty tubeswere implanted into the dorsal connective tissue of30 Wistar rats, which were arranged in five groupsaccording to the period of analysis: 7, 15, 30, 60and 90 days. After each experimental period, thetubes with surrounding tissue were removed and his-tologically processed to be analysed usinghaematoxylin–eosin and immunohistochemistry forthe detection of OCN, OPN and BSP. The data werestatistically analysed (Friedman’s test) at a 5% signifi-cance level.ResultsThe inflammatory response observed withBio-C Pulpo and White MTA-Ang was greater after 7and 15 days and decreased from 30 days onwards.No significant difference was found between the con-trol, Bio-C Pulpo and White MTA-Ang at the differentperiods of analysis (P>0.05). The immunolabellingfor OCN, OPN and BSP was more intense for Bio-CPulpo and White MTA-Ang after 60 and 90 days,but there was no difference between Bio-C Pulpo andWhite MTA-Ang at the different periods of analysis(P>0.05).ConclusionBio-C Pulpo is biocompatible andinduces immunolabelling of osteogenic markers suchas OCN, OPN and BSP similar to White MTA-Ang.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/iej.13052

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