Conjugated linoleic acid prevents damage caused by intestinal mucositis induced by 5-fluorouracil in an experimental model
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Universidade Federal de Minas Gerais
Descrição
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Artigo de periódico
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Membros da banca
Resumo
Background
Studies have showed the protective effects of conjugated linoleic acid (CLA) on intestinal epithelium, modulating host immune and inflammatory responses on intestinal diseases.
Objective
To evaluate the preventive effects of CLA on the intestinal mucositis induced by 5-FU in a murine model.
Methods
Sixty-four BALB/c mice were randomly divided into four groups: Control (CTL), fed a standard chow diet; CLAs, fed a diet supplemented with CLA; Mucositis (5-FU), fed a standard chow diet and underwent mucositis induction and CLAs 5-FU, fed a diet supplemented with CLA and underwent mucositis induction. Mucositis was induced by intraperitoneal injection of 300 mg/kg 5-FU. After 72 h, the animals were euthanized and intestinal permeability, bacterial translocation, inflammatory mediators, and intestinal histology were evaluated.
Results
Mice in the CLAs 5-FU group showed reduced weight loss compared to those in the 5-FU group (p < 0.005). Furthermore, the results also showed that the treatment with CLA reduced intestinal permeability, bacterial translocation, and biomarkers of inflammatory response besides minor damage to ZO-1 and occludin with maintenance of the integrity of the intestinal epithelium and a favorable balance between the inflammatory and regulatory cytokines.
Conclusion
This study suggests that CLA reduced the adverse effects from 5-FU administration on the intestinal mucosa.
Abstract
Assunto
Mucosite, Citocinas, Danos intestinais, Ácido linoleico
Palavras-chave
Mucositis, Intestinal damage, Conjugated linoleic acids, Tight junction protein, Cytokines, Bacterial translocation
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Endereço externo
https://www.sciencedirect.com/science/article/pii/S0753332218304402