Conjugated linoleic acid prevents damage caused by intestinal mucositis induced by 5-fluorouracil in an experimental model

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dc.creatorPatrícia Aparecida Vieira de Barros
dc.creatorMaria Emília Rabelo Andrade
dc.creatorSimone de Vasconcelos Generoso
dc.creatorSued Eustáquio Mendes Miranda
dc.creatorDiego Carlos dos Reis
dc.creatorPaola Caroline Lacerda Leocádio
dc.creatorÉricka Lorenna de Sales e Souza
dc.creatorFlaviano dos Santos Martins
dc.creatorMarco Antonio Sundfeld da Gama
dc.creatorGeovanni Dantas Cassali
dc.creatorJacqueline Isaura Alvarez Leite
dc.creatorSimone Odília Antunes Fernandes
dc.creatorValbert Nascimento Cardoso
dc.date.accessioned2022-05-13T20:21:11Z
dc.date.accessioned2025-09-08T23:59:52Z
dc.date.available2022-05-13T20:21:11Z
dc.date.issued2018-07
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipOutra Agência
dc.identifier.doi10.1016/j.biopha.2018.04.133
dc.identifier.issn0753-3322
dc.identifier.urihttps://hdl.handle.net/1843/41657
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBiomedicine & Pharmacotherapy
dc.rightsAcesso Restrito
dc.subjectMucosite
dc.subjectCitocinas
dc.subjectDanos intestinais
dc.subjectÁcido linoleico
dc.subject.otherMucositis
dc.subject.otherIntestinal damage
dc.subject.otherConjugated linoleic acids
dc.subject.otherTight junction protein
dc.subject.otherCytokines
dc.subject.otherBacterial translocation
dc.titleConjugated linoleic acid prevents damage caused by intestinal mucositis induced by 5-fluorouracil in an experimental model
dc.typeArtigo de periódico
local.citation.epage1576
local.citation.spage1567
local.citation.volume103
local.description.resumoBackground Studies have showed the protective effects of conjugated linoleic acid (CLA) on intestinal epithelium, modulating host immune and inflammatory responses on intestinal diseases. Objective To evaluate the preventive effects of CLA on the intestinal mucositis induced by 5-FU in a murine model. Methods Sixty-four BALB/c mice were randomly divided into four groups: Control (CTL), fed a standard chow diet; CLAs, fed a diet supplemented with CLA; Mucositis (5-FU), fed a standard chow diet and underwent mucositis induction and CLAs 5-FU, fed a diet supplemented with CLA and underwent mucositis induction. Mucositis was induced by intraperitoneal injection of 300 mg/kg 5-FU. After 72 h, the animals were euthanized and intestinal permeability, bacterial translocation, inflammatory mediators, and intestinal histology were evaluated. Results Mice in the CLAs 5-FU group showed reduced weight loss compared to those in the 5-FU group (p < 0.005). Furthermore, the results also showed that the treatment with CLA reduced intestinal permeability, bacterial translocation, and biomarkers of inflammatory response besides minor damage to ZO-1 and occludin with maintenance of the integrity of the intestinal epithelium and a favorable balance between the inflammatory and regulatory cytokines. Conclusion This study suggests that CLA reduced the adverse effects from 5-FU administration on the intestinal mucosa.
local.publisher.countryBrasil
local.publisher.departmentENF - DEPARTAMENTO DE NUTRIÇÃO
local.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOS
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0753332218304402

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