Magnetic nanoparticles coated with cyclodextrins and citrate for irinotecan delivery
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Resumo
In the present work, we study the role of different components in the formation of more stable iron oxide magnetic nanoparticles (MNPs): β-cyclodextrin (BCD), 2-hydroxypropyl-β-cyclodextrin (HP) and citrate anion. MNPs formulations were characterized by FTIR, particles size measurements, zeta potential based on dynamic light scattering principle technique, X-ray powder pattern diffraction, XPS spectroscopy, transmission electron microscopy and thermogravimetric analysis. The results showed that cyclodextrins and citrate plays a key role in order to obtain a lower size of coated MNPs and proved to be an efficient strategy to obtain a more stable colloidal dispersion, avoiding the nanoparticles oxidation, enhancing the irinotecan incorporation and release. Furthermore, citrate-coated BCD-MNPs showed the same cytotoxicity of the free IRI.
Abstract
Assunto
Ciclodextrinas, Nanopartículas, Sistemas de distribuição de medicamentos, Câncer - Tratamento, Potencial zeta, Luz - Espalhamento, Termogravimetria, Microscopia eletrônica - Técnica, Raios X - Difração, Fourier, Espectroscopia de infravermelho por transformada de
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Cancer, Citrate, Cyclodextrin, Irinotecan, Magnetic nanoparticle
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https://www.sciencedirect.com/science/article/pii/S0144861716313698