Magnetic nanoparticles coated with cyclodextrins and citrate for irinotecan delivery

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dc.creatorAna Paula de Figueiredo Monteiro
dc.creatorLarissa Durães Caminhas
dc.creatorJosé Domingos Ardisson
dc.creatorRoberto Magalhães Paniago
dc.creatorMaría Esperanza Cortés Segura
dc.creatorRubén Dario Sinisterra Millán
dc.date.accessioned2023-12-04T14:18:35Z
dc.date.accessioned2025-09-09T01:13:03Z
dc.date.available2023-12-04T14:18:35Z
dc.date.issued2017-05
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipINCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio)
dc.identifier.doihttps://doi.org/10.1016/j.carbpol.2016.11.091
dc.identifier.issn1879-1344
dc.identifier.urihttps://hdl.handle.net/1843/61673
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofCarbohydrate Polymers
dc.rightsAcesso Aberto
dc.subjectCiclodextrinas
dc.subjectNanopartículas
dc.subjectSistemas de distribuição de medicamentos
dc.subjectCâncer - Tratamento
dc.subjectPotencial zeta
dc.subjectLuz - Espalhamento
dc.subjectTermogravimetria
dc.subjectMicroscopia eletrônica - Técnica
dc.subjectRaios X - Difração
dc.subjectFourier, Espectroscopia de infravermelho por transformada de
dc.subject.otherCancer
dc.subject.otherCitrate
dc.subject.otherCyclodextrin
dc.subject.otherIrinotecan
dc.subject.otherMagnetic nanoparticle
dc.titleMagnetic nanoparticles coated with cyclodextrins and citrate for irinotecan delivery
dc.typeArtigo de periódico
local.citation.epage9
local.citation.spage1
local.citation.volume163
local.description.resumoIn the present work, we study the role of different components in the formation of more stable iron oxide magnetic nanoparticles (MNPs): β-cyclodextrin (BCD), 2-hydroxypropyl-β-cyclodextrin (HP) and citrate anion. MNPs formulations were characterized by FTIR, particles size measurements, zeta potential based on dynamic light scattering principle technique, X-ray powder pattern diffraction, XPS spectroscopy, transmission electron microscopy and thermogravimetric analysis. The results showed that cyclodextrins and citrate plays a key role in order to obtain a lower size of coated MNPs and proved to be an efficient strategy to obtain a more stable colloidal dispersion, avoiding the nanoparticles oxidation, enhancing the irinotecan incorporation and release. Furthermore, citrate-coated BCD-MNPs showed the same cytotoxicity of the free IRI.
local.identifier.orcidhttps://orcid.org/0000-0002-4202-1964
local.identifier.orcidhttps://orcid.org/0000-0001-7657-9360
local.identifier.orcidhttps://orcid.org/0000-0002-5615-3482
local.identifier.orcidhttps://orcid.org/0000-0002-0540-7163
local.identifier.orcidhttps://orcid.org/0000-0002-0560-8491
local.identifier.orcidhttps://orcid.org/0000-0001-7656-1849
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.departmentICX - DEPARTAMENTO DE FÍSICA
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0144861716313698

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