Ten-year kidney transplant survival of cyclosporine- or tacrolimus-treated patients in Brazil
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Membros da banca
Resumo
Background: Cyclosporine and tacrolimus are well established immunosuppressants; however little know about long term survival rates. Aim: Compare 10-year graft survival and associated factors among kidney transplant patients within the Brazilian Public Health system (SUS) prescribed either medicine. Methods: Analyze a national cohort of kidney transplant recipients within SUS. Graft loss defined by death or dialysis for more than three months. Kaplan-Meier method used to estimate cumulative probabilities of survival. Cox proportional hazards modelused to evaluate factors associated with progression to graft loss. Results: 13,811 patients were included, 5,887 used cyclosporine and 7,924 tacrolimus. A higher risk of graft loss was associated with tacrolimus, a deceased donor, additional years of age, median period of dialysis greater than 47 months, diagnosis of diabetes as the primary cause of chronic kidney disease
and transplantation between 2005 and 2009. Conclusions: Among other factors, tacrolimus based regimens were associated with worse graft survival.
Abstract
Assunto
Transplante de Rim, Análise de Sobrevida, Ciclosporina, Estimativa de Kaplan-Meier
Palavras-chave
Kidney Transplantation, survival analysis, Cyclosporine
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https://www.tandfonline.com/doi/abs/10.1080/17512433.2016.1190270