Ten-year kidney transplant survival of cyclosporine- or tacrolimus-treated patients in Brazil

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dc.creatorRosângela Maria Gomes
dc.creatorBrian Godman
dc.creatorFrancisco de Assis Acurcio
dc.creatorAugusto Afonso Guerra Júnior
dc.creatorLívia Lovato Pires de Lemos
dc.creatorJuliana de Oliveira Costa
dc.creatorAlessandra Almeida Maciel
dc.creatorJuliana Alvares
dc.creatorCharles Simão Filho
dc.creatorMariângela Leal Cherchiglia
dc.creatorEli Iola Gurgel Andrade
dc.date.accessioned2023-08-03T22:30:52Z
dc.date.accessioned2025-09-09T01:18:37Z
dc.date.available2023-08-03T22:30:52Z
dc.date.issued2016
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1080/17512433.2016.1190270
dc.identifier.issn1751-2433
dc.identifier.urihttps://hdl.handle.net/1843/57446
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofExpert Review of Clinical Pharmacology
dc.rightsAcesso Restrito
dc.subjectTransplante de Rim
dc.subjectAnálise de Sobrevida
dc.subjectCiclosporina
dc.subjectEstimativa de Kaplan-Meier
dc.subject.otherKidney Transplantation
dc.subject.othersurvival analysis
dc.subject.otherCyclosporine
dc.titleTen-year kidney transplant survival of cyclosporine- or tacrolimus-treated patients in Brazil
dc.typeArtigo de periódico
local.citation.epage999
local.citation.issue7
local.citation.spage991
local.citation.volume9
local.description.resumoBackground: Cyclosporine and tacrolimus are well established immunosuppressants; however little know about long term survival rates. Aim: Compare 10-year graft survival and associated factors among kidney transplant patients within the Brazilian Public Health system (SUS) prescribed either medicine. Methods: Analyze a national cohort of kidney transplant recipients within SUS. Graft loss defined by death or dialysis for more than three months. Kaplan-Meier method used to estimate cumulative probabilities of survival. Cox proportional hazards modelused to evaluate factors associated with progression to graft loss. Results: 13,811 patients were included, 5,887 used cyclosporine and 7,924 tacrolimus. A higher risk of graft loss was associated with tacrolimus, a deceased donor, additional years of age, median period of dialysis greater than 47 months, diagnosis of diabetes as the primary cause of chronic kidney disease and transplantation between 2005 and 2009. Conclusions: Among other factors, tacrolimus based regimens were associated with worse graft survival.
local.identifier.orcid0000-003-4119-8925
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE FARMÁCIA SOCIAL
local.publisher.departmentMED - DEPARTAMENTO DE CIRURGIA
local.publisher.departmentMED - DEPARTAMENTO DE MEDICINA PREVENTIVA SOCIAL
local.publisher.initialsUFMG
local.url.externahttps://www.tandfonline.com/doi/abs/10.1080/17512433.2016.1190270

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