Pretreatment and treatment with fructo-oligosaccharides attenuate intestinal mucositis induced by 5-FU in mice
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Membros da banca
Resumo
Mucositis is a side effect observed in patients undergoing chemotherapy. Besides, this treatment also leads to the imbalance of the intestinal microbiota. This study evaluated the effects of pre and treatment with fructo-oligosaccharides (FOS) in intestinal mucositis induced by 5-fluorouracil (5-FU). Balb/c mice were divided into four groups: CTL (without mucositis + saline), MUC (mucositis + saline), PT (mucositis + 6% FOS before disease induction) and T (mucositis + 6% FOS after disease induction). Mucositis was induced with an intraperitoneal injection of 300 mg/kg 5-FU. After 72 h intestinal permeability (IP), inflammatory infiltrate, oxidative stress, histological analysis, and short-chain fatty acids (SCFA) production were evaluated. The MUC group showed lost weight, intense inflammatory infiltrate, increased oxidative stress and IP (P < 0.05). FOS supplementation attenuated all these parameters (P < 0.05). Only pretreatment was able to maintain the acetate and butyrate production. These results showed that FOS supplementation presented protective effects on intestinal barrier function.
Abstract
Assunto
Mucosite intestinal, Permeabilidade intestinal, fruto-oligossacarídeo, Camundongos
Palavras-chave
Mucositis, Fructo-oligosaccharides, 5-fluorouracil, Intestinal permeability
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https://www.sciencedirect.com/science/article/pii/S1756464618304869?via%3Dihub#!