Pretreatment and treatment with fructo-oligosaccharides attenuate intestinal mucositis induced by 5-FU in mice

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dc.creatorFlavia Mendes Peradeles Galdino
dc.creatorMaria Emília Rabelo Andrade
dc.creatorPatrícia Aparecida Vieira de Barros
dc.creatorSimone de Vasconcelos Generoso
dc.creatorJacqueline Isaura Alvarez-Leite
dc.creatorCamila Megale de Almeida-Leite
dc.creatorMaria do Carmo Gouveia Peluzio
dc.creatorSimone Odília Antunes Fernandes
dc.creatorValbert Nascimento Cardoso
dc.date.accessioned2022-05-12T21:18:30Z
dc.date.accessioned2025-09-09T00:21:30Z
dc.date.available2022-05-12T21:18:30Z
dc.date.issued2018-10
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.identifier.doi10.1016/j.jff.2018.09.012
dc.identifier.issn1756-4646
dc.identifier.urihttps://hdl.handle.net/1843/41626
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Functional Foods
dc.rightsAcesso Restrito
dc.subjectMucosite intestinal
dc.subjectPermeabilidade intestinal
dc.subjectfruto-oligossacarídeo
dc.subjectCamundongos
dc.subject.otherMucositis
dc.subject.otherFructo-oligosaccharides
dc.subject.other5-fluorouracil
dc.subject.otherIntestinal permeability
dc.titlePretreatment and treatment with fructo-oligosaccharides attenuate intestinal mucositis induced by 5-FU in mice
dc.typeArtigo de periódico
local.citation.epage492
local.citation.spage485
local.citation.volume49
local.description.resumoMucositis is a side effect observed in patients undergoing chemotherapy. Besides, this treatment also leads to the imbalance of the intestinal microbiota. This study evaluated the effects of pre and treatment with fructo-oligosaccharides (FOS) in intestinal mucositis induced by 5-fluorouracil (5-FU). Balb/c mice were divided into four groups: CTL (without mucositis + saline), MUC (mucositis + saline), PT (mucositis + 6% FOS before disease induction) and T (mucositis + 6% FOS after disease induction). Mucositis was induced with an intraperitoneal injection of 300 mg/kg 5-FU. After 72 h intestinal permeability (IP), inflammatory infiltrate, oxidative stress, histological analysis, and short-chain fatty acids (SCFA) production were evaluated. The MUC group showed lost weight, intense inflammatory infiltrate, increased oxidative stress and IP (P < 0.05). FOS supplementation attenuated all these parameters (P < 0.05). Only pretreatment was able to maintain the acetate and butyrate production. These results showed that FOS supplementation presented protective effects on intestinal barrier function.
local.publisher.countryBrasil
local.publisher.departmentENF - DEPARTAMENTO DE NUTRIÇÃO
local.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOS
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S1756464618304869?via%3Dihub#!

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