Caga-positive helicobacter pylori strain containing three epiya c phosphorylation sites produces increase of g cell and decrease of d cell in experimentally infected gerbils (meriones unguiculatus)

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dc.creatorMoacir Ferreira Júnior
dc.creatorSérgio de Assis Batista
dc.creatorRafael Calvão Barbuto
dc.creatorAdriana Dias Gomes
dc.creatorDulciene Maria Magalhães Queiroz
dc.creatorIvana Duval Araújo
dc.creatorMarcelo Vidigal Caliari
dc.date.accessioned2023-06-02T20:16:09Z
dc.date.accessioned2025-09-08T23:49:56Z
dc.date.available2023-06-02T20:16:09Z
dc.date.issued2016-02-23
dc.format.mimetypepdf
dc.identifier.doi10.1016/j.advms.2016.02.003
dc.identifier.issn18961126
dc.identifier.urihttps://hdl.handle.net/1843/54409
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofAdvances in Medical Sciences
dc.rightsAcesso Restrito
dc.subjectHelicobacter pylori
dc.subjectCélulas Secretoras de Gastrina
dc.subjectCélulas Secretoras de Somatostatina
dc.subject.otherHelicobacter pylori
dc.subject.otherG cells
dc.subject.otherCélulas Secretoras de Somatostatina
dc.subject.otherCag A
dc.titleCaga-positive helicobacter pylori strain containing three epiya c phosphorylation sites produces increase of g cell and decrease of d cell in experimentally infected gerbils (meriones unguiculatus)
dc.typeArtigo de periódico
local.citation.epage236
local.citation.issue2
local.citation.spage231
local.citation.volume61
local.description.resumoPurpose: Human infection by Helicobacter pylori is associated with an increase in the number of gastrin producing G cells and a concomitant decrease of somatostatin-producing D cells. However, to our knowledge, changes in G and D cell numbers in response to infection with H. pylori CagA-positive strains containing different number of EPIYA-C phosphorylation sites have not been analyzed to date. Therefore,the aim of this study was to perform a quantitative analysis of the number of G and D cells in Mongolian gerbils challenged with H. pylori strains with different numbers of EPIYA-C motifs.Materials and methods: Mongolian gerbils were inoculated with isogenic H. pylori strains containing one to three phosphorylation sites. Mucosal fragments were evaluated by morphometry and immunohistochemistry using primary polyclonal rabbit anti-gastrin and anti-somatostatin antibodies. Positive cells were counted using an image analyzer.Results: Forty-five days after infection, there was a decrease in the number of D cells and an increase inthe G/D cell ratio in the group with three EPIYA-C. Six months after infection, there was a progressive and significant increase in the number of G cells and in the G/D cell ratio, with a concomitant decrease in thenumber of D cells, especially in the three EPIYA-C group.Conclusions: CagA-positive H. pylori strains containing a large number of EPIYA-C phosphorylation sites induce a decrease in D cell number and an increase in G cell number and G/D ratio, which were correlated with the number of inflammatory cells of the lamina propria.
local.identifier.orcidhttps://orcid.org/0000-0001-6488-734X
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE CIRURGIA
local.publisher.departmentMED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTAR
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S1896112616000158?via%3Dihub

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