The structure of the extended E2 DNA-binding domain of the bovine papillomavirus-1
Carregando...
Data
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Federal de Minas Gerais
Descrição
Tipo
Artigo de periódico
Título alternativo
Primeiro orientador
Membros da banca
Resumo
Bovine papillomavirus proteins were extensively studied as a prototype for the human papillomavirus. Here, the crystal structure of the extended E2 DNA-binding domain of the dominant transcription regulator from the bovine papillomavirus strain 1 is described in the space group P3121. We found two protein functional dimers packed in the asymmetric unit. This new protein arrangement inside the crystal led to the reduction of the mobility of a previously unobserved loop directly involved in the protein-DNA interaction, which was then modeled for the first time.
Abstract
Assunto
Papilomavírus
Palavras-chave
Bovine papillomavirus, E2 DNA-binding domain, LI loop, Protein structure
Citação
Departamento
Curso
Endereço externo
https://onlinelibrary.wiley.com/doi/10.1002/prot.25773