The structure of the extended E2 DNA-binding domain of the bovine papillomavirus-1

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dc.creatorLudmila Maria Diniz Leroy
dc.creatorJoão Alexandre Ribeiro Gonçalves Barbosa
dc.creatorGonzalo de Prat Gay
dc.creatorIgor Polikarpov
dc.creatorCarlos Basílio Pinheiro
dc.date.accessioned2023-07-31T12:02:52Z
dc.date.accessioned2025-09-08T23:20:19Z
dc.date.available2023-07-31T12:02:52Z
dc.date.issued2019
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1002/prot.25773
dc.identifier.issn1097-0134
dc.identifier.urihttps://hdl.handle.net/1843/57197
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPROTEINS: Structure, Function, and Bioinformatics
dc.rightsAcesso Restrito
dc.subjectPapilomavírus
dc.subject.otherBovine papillomavirus
dc.subject.otherE2 DNA-binding domain
dc.subject.otherLI loop
dc.subject.otherProtein structure
dc.titleThe structure of the extended E2 DNA-binding domain of the bovine papillomavirus-1
dc.typeArtigo de periódico
local.citation.epage112
local.citation.issue1
local.citation.spage106
local.citation.volume88
local.description.resumoBovine papillomavirus proteins were extensively studied as a prototype for the human papillomavirus. Here, the crystal structure of the extended E2 DNA-binding domain of the dominant transcription regulator from the bovine papillomavirus strain 1 is described in the space group P3121. We found two protein functional dimers packed in the asymmetric unit. This new protein arrangement inside the crystal led to the reduction of the mobility of a previously unobserved loop directly involved in the protein-DNA interaction, which was then modeled for the first time.
local.identifier.orcidhttps://orcid.org/0000-0002-4272-0298
local.identifier.orcidhttps://orcid.org/0000-0002-0534-481X
local.identifier.orcidhttps://orcid.org/0000-0001-5748-6863
local.identifier.orcidhttps://orcid.org/0000-0001-9496-4174
local.identifier.orcidhttps://orcid.org/0000-0002-8674-1779
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE FÍSICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1002/prot.25773

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