Urease inhibitors of agricultural interest inspired by structures of plant phenolic aldehydes
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Resumo
The plant phenolic natural products (PNPs) protocatechuic aldehyde, syringaldehyde and vanillin were used as platforms for obtaining four urease inhibitors. Urea (urease substrate) or thiourea (urease inhibitor) core was added to the structure of newly synthesized compounds to provide inhibitors up to 230-fold more active than the PNPs they originated from. The PNP derivatives are mixed inhibitors with higher affinity to urease active site. Two compounds were as efficient as N-(butyl)thiophosphoric triamide (NBPT) toward soil. Overall, PNPs derivatives are promising urease inhibitors for use as additive in urea-based fertilizers formulations.
Abstract
Assunto
Ureia como fertilizante, Química, Produtos naturais, Fenóis, Inibidores - Urease, Aldeídos
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Urea, Urease inhibitors, Natural products, Phenolic aldehydes, Fertilizer additive
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https://www.scielo.br/j/jbchs/a/yjZC8mqjtfrtj7styVFfXnb/