Urease inhibitors of agricultural interest inspired by structures of plant phenolic aldehydes

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dc.creatorLívia Pereira Horta
dc.creatorYane Campolina Cachuite Mota
dc.creatorGisele Maria Barbosa
dc.creatorTaniris Cafiero Braga
dc.creatorIvanildo Evódio Marriel
dc.creatorÂngelo de Fátima
dc.creatorLuzia Valentina Modolo
dc.date.accessioned2023-12-26T18:16:05Z
dc.date.accessioned2025-09-09T00:47:11Z
dc.date.available2023-12-26T18:16:05Z
dc.date.issued2016
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipOutra Agência
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.21577/0103-5053.20160208
dc.identifier.issn1678-4790
dc.identifier.urihttps://hdl.handle.net/1843/62178
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of the Brazilian Chemical Society
dc.rightsAcesso Aberto
dc.subjectUreia como fertilizante
dc.subjectQuímica
dc.subjectProdutos naturais
dc.subjectFenóis
dc.subjectInibidores - Urease
dc.subjectAldeídos
dc.subject.otherUrea
dc.subject.otherUrease inhibitors
dc.subject.otherNatural products
dc.subject.otherPhenolic aldehydes
dc.subject.otherFertilizer additive
dc.titleUrease inhibitors of agricultural interest inspired by structures of plant phenolic aldehydes
dc.typeArtigo de periódico
local.citation.epage1519
local.citation.issue8
local.citation.spage1512
local.citation.volume27
local.description.resumoThe plant phenolic natural products (PNPs) protocatechuic aldehyde, syringaldehyde and vanillin were used as platforms for obtaining four urease inhibitors. Urea (urease substrate) or thiourea (urease inhibitor) core was added to the structure of newly synthesized compounds to provide inhibitors up to 230-fold more active than the PNPs they originated from. The PNP derivatives are mixed inhibitors with higher affinity to urease active site. Two compounds were as efficient as N-(butyl)thiophosphoric triamide (NBPT) toward soil. Overall, PNPs derivatives are promising urease inhibitors for use as additive in urea-based fertilizers formulations.
local.identifier.orcidhttps://orcid.org/0000-0002-2853-2215
local.identifier.orcidhttps://orcid.org/0000-0002-4032-0100
local.identifier.orcidhttps://orcid.org/0000-0002-1670-0285
local.identifier.orcidhttps://orcid.org/0000-0003-2344-5590
local.identifier.orcidhttps://orcid.org/0000-0002-8033-0434
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE BOTÂNICA
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/jbchs/a/yjZC8mqjtfrtj7styVFfXnb/

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