Efficacy of B-lactam/B-lactamase inhibitor combinations for the treatment of bloodstream infection due to extended-spectrum B-lactamase-producing enterobacteriaceae in hematological patients with neutropenia
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Membros da banca
Resumo
ß-Lactam/ß-lactamase inhibitors (BLBLIs) were compared to carbapenems in two cohorts of hematological neutropenic patients with extended-spectrum- -lactamase (ESBL) bloodstream infection (BSI): the empirical therapy cohort (174 patients) and the definitive therapy cohort (251 patients). The 30-day case fatality rates and other secondary outcomes were similar in the two therapy groups of the two cohorts and also in the propensity-matched cohorts. BLBLIs might be carbapenem sparing alternatives for the treatment of BSI due to ESBLs in these patients.
Abstract
Assunto
Sepse, Neutropenia, Inibidores de beta-Lactamases
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ESBLs, Bloodstream infection, Neutropenia, beta-lactam/beta-lactamase inhibitors, Inibidores de beta-Lactamases
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https://journals.asm.org/doi/10.1128/aac.00164-17