Association between components of metabolic syndrome and periodontitis: a systematic review and meta‑analysis
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Objectives: To evaluate the role of metabolic syndrome (MetS) components in the association with periodontitis (PE) (#CRD42020218310). Materials and methods: A systematic electronic search was performed in PUBMED, Scielo and Lilacs databases up to April 2022. Cross-sectional, case–control, and cohort studies presenting data on the association between MetS and PE in the adult and elderly populations were included. A random effect meta-analysis was performed to determine association effect estimates. Results interpretation followed the assessment of methodological quality (Joana Briggs Institute tool) together with the certainty of evidence (GRADE approach). Results: This review included 52 studies, totalling 140,434 participants, and 38 studies were meta-analyzed. Association between PE and MetS was observed (ORadj from 1.27 to 1.90; PRajd = 1.19; RRadj from 1.10 to 1.37) (low and very low certainty of evidence). Hyperglycaemia (OR = 1.18), HDL (OR = 1.16), obesity (OR = 1.08), and hypertension (OR = 1.11) were associated with PE, except triglycerides (low and very low certainty of evidence). There was a dose–response gradient between the number of MetS components and PE, with a gradual increase in the effect magnitude for 1 (OR = 1.14), 2 (OR = 1.52), 3 or more (OR = 1.79), and 4 or 5 components (OR = 2.02) (low to high certainty of evidence). Conclusions: MetS was associated with PE, with a dose–response gradient between the number of MetS components and the occurrence of PE, with an increasing effect magnitude according to an increasing number of components. Clinical relevance: Periodontal examination should be part of a comprehensive propaedeutic approach of MetS patients, particularly those presenting a great number of components.
Abstract
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Hyperglycemia, Hypertension, Metabolic syndrome, Obesity, Periodontal diseases, Periodontitis
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Hyperglycemia, Hypertension, Metabolic syndrome, Obesity, Periodontal diseases, Periodontitis
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https://link.springer.com/article/10.1007/s00784-022-04583-x