DNA/TNA mesoscopic modeling of melting temperatures suggests weaker hydrogen bonding of CG than in DNA/RNA
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Membros da banca
Resumo
TNA/DNA hybrids share several similarities to RNA/DNA, such as the tendency to form A-type helices and a strong dependency of their thermodynamic properties on purine/pyrimidine ratio. However, unlike RNA/DNA, not much is known about the base-pair properties of TNA. Here, we use a mesoscopic analysis of measured melting temperatures to obtain an estimate of hydrogen bonds and stacking interactions. Our results reveal that the AT base pairs in TNA/DNA have nearly identical hydrogen bond strengths than their counterparts in RNA/DNA, but surprisingly CG turned out to be much weaker despite similar stability.
Abstract
Assunto
DNA, Hidrogênio
Palavras-chave
DNA/TNA hybrid, Peyrard-Bishop DNA model, DNA/TNA stability, Hydrogen bonds, Stacking interaction
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Endereço externo
https://www.sciencedirect.com/science/article/pii/S0009261420303286