DNA/TNA mesoscopic modeling of melting temperatures suggests weaker hydrogen bonding of CG than in DNA/RNA

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dc.creatorMaria Izabel Muniz Foscarini
dc.creatorHershel H. Lackey
dc.creatorJennifer Margaret Heemstra
dc.creatorGerald Weber
dc.date.accessioned2025-02-25T18:27:06Z
dc.date.accessioned2025-09-09T00:06:18Z
dc.date.available2025-02-25T18:27:06Z
dc.date.issued2020
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.cplett.2020.137413
dc.identifier.issn1873-4448
dc.identifier.urihttps://hdl.handle.net/1843/80434
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofChemical Physics Letters
dc.rightsAcesso Aberto
dc.subjectDNA
dc.subjectHidrogênio
dc.subject.otherDNA/TNA hybrid
dc.subject.otherPeyrard-Bishop DNA model
dc.subject.otherDNA/TNA stability
dc.subject.otherHydrogen bonds
dc.subject.otherStacking interaction
dc.titleDNA/TNA mesoscopic modeling of melting temperatures suggests weaker hydrogen bonding of CG than in DNA/RNA
dc.typeArtigo de periódico
local.citation.epage6
local.citation.spage1
local.citation.volume749
local.description.resumoTNA/DNA hybrids share several similarities to RNA/DNA, such as the tendency to form A-type helices and a strong dependency of their thermodynamic properties on purine/pyrimidine ratio. However, unlike RNA/DNA, not much is known about the base-pair properties of TNA. Here, we use a mesoscopic analysis of measured melting temperatures to obtain an estimate of hydrogen bonds and stacking interactions. Our results reveal that the AT base pairs in TNA/DNA have nearly identical hydrogen bond strengths than their counterparts in RNA/DNA, but surprisingly CG turned out to be much weaker despite similar stability.
local.identifier.orcidhttps://orcid.org/0009-0005-1571-6516
local.identifier.orcidhttps://orcid.org/0000-0001-9132-5764
local.identifier.orcidhttps://orcid.org/0000-0002-2935-1571
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE FÍSICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0009261420303286

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